BDBM50152397 4-[6-Methoxy-7-(2-morpholin-4-yl-ethoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (5-methyl-pyrazin-2-ylmethyl)-amide::CHEMBL186612
SMILES: COc1cc2c(ncnc2cc1OCCN1CCOCC1)N1CCN(CC1)C(=S)NCc1cnc(C)cn1
InChI Key: InChIKey=URKTWKNEBOKMRA-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM50152397 (4-[6-Methoxy-7-(2-morpholin-4-yl-ethoxy)-quinazoli...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
and In Vivo Sciences Millennium Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description In vitro inhibition of Platelet derived growth factor receptor beta autophosphorylation in MG-63 cells without plasma | Bioorg Med Chem Lett 14: 4867-72 (2004) Article DOI: 10.1016/j.bmcl.2004.07.041 BindingDB Entry DOI: 10.7270/Q2VM4BQN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM50152397 (4-[6-Methoxy-7-(2-morpholin-4-yl-ethoxy)-quinazoli...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
and In Vivo Sciences Millennium Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description In vitro inhibition of Platelet derived growth factor receptor beta autophosphorylation in MG-63 cells with 45% human plasma | Bioorg Med Chem Lett 14: 4867-72 (2004) Article DOI: 10.1016/j.bmcl.2004.07.041 BindingDB Entry DOI: 10.7270/Q2VM4BQN | |||||||||||
More data for this Ligand-Target Pair |