BDBM50152714 (R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethyl)-5-(5-chlorothiophen-2-yl)-6-methylpyrimidine-2,4(1H,3H)-dione::3-((R)-2-Amino-2-phenyl-ethyl)-5-(5-chloro-thiophen-2-yl)-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione::CHEMBL363759

SMILES: Cc1c(-c2ccc(Cl)s2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F

InChI Key: InChIKey=PHXPRFGABKXMTN-IBGZPJMESA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50152714   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gonadotropin releasing hormone 1 (GnRHR1) (Homo sapiens (Human))	BDBM50152714 ((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...) Show SMILES Cc1c(-c2ccc(Cl)s2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F |r| Show InChI InChI=1S/C24H20ClF2N3O2S/c1-14-22(20-10-11-21(25)33-20)23(31)30(13-19(28)15-6-3-2-4-7-15)24(32)29(14)12-16-17(26)8-5-9-18(16)27/h2-11,19H,12-13,28H2,1H3/t19-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc Curated by ChEMBL					Assay Description Binding affinity at human GnRH receptor				J Med Chem 51: 3331-48 (2008) Article DOI: 10.1021/jm701249f BindingDB Entry DOI: 10.7270/Q2KD1XQ0
					More data for this Ligand-Target Pair
Gonadotropin releasing hormone 1 (GnRHR1) (Homo sapiens (Human))	BDBM50152714 ((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...) Show SMILES Cc1c(-c2ccc(Cl)s2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F |r| Show InChI InChI=1S/C24H20ClF2N3O2S/c1-14-22(20-10-11-21(25)33-20)23(31)30(13-19(28)15-6-3-2-4-7-15)24(32)29(14)12-16-17(26)8-5-9-18(16)27/h2-11,19H,12-13,28H2,1H3/t19-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards cloned human Gonadotropin-releasing hormone receptor expressed in RBL cells was determined by using [125I]-GnRH as radioliga...				Bioorg Med Chem Lett 14: 4967-73 (2004) Article DOI: 10.1016/j.bmcl.2004.07.022 BindingDB Entry DOI: 10.7270/Q2FF3RT4
					More data for this Ligand-Target Pair