null

SMILES: Cc1cc(cc(C)c1C)-c1c(OCC[C@@H]2CCCN2)c2cc(C(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O

InChI Key: InChIKey=HOLPQAAWTOLBOD-FQEVSTJZSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50155365   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50155365 (7-Chloro-2-oxo-4-(2-pyrrolidin-2-yl-ethoxy)-3-((S)...) Show SMILES Cc1cc(cc(C)c1C)-c1c(OCC[C@@H]2CCCN2)c2cc(C(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O Show InChI InChI=1S/C29H30ClN5O3/c1-16-11-19(12-17(2)18(16)3)26-27(38-10-7-20-5-4-8-32-20)22-13-21(23(30)14-24(22)34-29(26)37)28(36)35-25-6-9-31-15-33-25/h6,9,11-15,20,32H,4-5,7-8,10H2,1-3H3,(H,34,37)(H,31,33,35,36)/t20-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of GnRH-stimulated phosphatidyl inositol hydrolysis in CHO cells expressing GnRH receptor				Bioorg Med Chem Lett 14: 5599-603 (2004) Article DOI: 10.1016/j.bmcl.2004.08.056 BindingDB Entry DOI: 10.7270/Q20V8C8D
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50155365 (7-Chloro-2-oxo-4-(2-pyrrolidin-2-yl-ethoxy)-3-((S)...) Show SMILES Cc1cc(cc(C)c1C)-c1c(OCC[C@@H]2CCCN2)c2cc(C(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O Show InChI InChI=1S/C29H30ClN5O3/c1-16-11-19(12-17(2)18(16)3)26-27(38-10-7-20-5-4-8-32-20)22-13-21(23(30)14-24(22)34-29(26)37)28(36)35-25-6-9-31-15-33-25/h6,9,11-15,20,32H,4-5,7-8,10H2,1-3H3,(H,34,37)(H,31,33,35,36)/t20-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards human gonadotropin releasing hormone receptor expressed in CHO cells was determined by using [125I]-buserelin as radioligand				Bioorg Med Chem Lett 14: 5599-603 (2004) Article DOI: 10.1016/j.bmcl.2004.08.056 BindingDB Entry DOI: 10.7270/Q20V8C8D
					More data for this Ligand-Target Pair