BDBM50155652 3-Diethylamino-N-[6-(3-diethylamino-propionylamino)-9-oxo-9,10-dihydro-acridin-3-yl]-propionamide::CHEMBL1080436::CHEMBL362887
SMILES: CCN(CC)CCC(=O)Nc1ccc2c(O)c3ccc(NC(=O)CCN(CC)CC)cc3nc2c1
InChI Key: InChIKey=OZPBMVWVOOUJFN-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50155652 (3-Diethylamino-N-[6-(3-diethylamino-propionylamino...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Central University of Las Villas Curated by ChEMBL | Assay Description Inhibition of telomerase in human A2780 cells by TRAP assay | Eur J Med Chem 44: 4826-40 (2009) Article DOI: 10.1016/j.ejmech.2009.07.029 BindingDB Entry DOI: 10.7270/Q20R9PHM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Telomerase reverse transcriptase (Homo sapiens (Human)) | BDBM50155652 (3-Diethylamino-N-[6-(3-diethylamino-propionylamino...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a |
University of London Curated by ChEMBL | Assay Description Concentration required to inhibit 50% of telomerase activity | Bioorg Med Chem Lett 14: 5845-9 (2004) Article DOI: 10.1016/j.bmcl.2004.09.037 BindingDB Entry DOI: 10.7270/Q26D5SG9 | |||||||||||
More data for this Ligand-Target Pair |