BDBM50156124 CHEMBL3781528

SMILES: Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCc2ccccn2)c2ccccc12)C(C)(C)C

InChI Key: InChIKey=BYSUPEAEGZRXIT-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50156124   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 12 (Homo sapiens (Human))	BDBM50156124 (CHEMBL3781528) Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCc2ccccn2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C32H33N5O2/c1-22-12-14-24(15-13-22)37-30(21-29(36-37)32(2,3)4)35-31(38)34-27-16-17-28(26-11-6-5-10-25(26)27)39-20-18-23-9-7-8-19-33-23/h5-17,19,21H,18,20H2,1-4H3,(H2,34,35,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sygnature Discovery Limited Curated by ChEMBL					Assay Description Inhibition of human recombinant p38 gamma assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...				J Med Chem 59: 1727-46 (2016) BindingDB Entry DOI: 10.7270/Q2319XRB
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50156124 (CHEMBL3781528) Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCc2ccccn2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C32H33N5O2/c1-22-12-14-24(15-13-22)37-30(21-29(36-37)32(2,3)4)35-31(38)34-27-16-17-28(26-11-6-5-10-25(26)27)39-20-18-23-9-7-8-19-33-23/h5-17,19,21H,18,20H2,1-4H3,(H2,34,35,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	167	n/a	n/a	n/a	n/a	n/a	n/a
Sygnature Discovery Limited Curated by ChEMBL					Assay Description Inhibition of human recombinant p38 alpha assessed as phosphorylation of MAPKAP-K2 preincubated for 2 hrs followed by FRET peptide and MAPKAP-K2 addi...				J Med Chem 59: 1727-46 (2016) BindingDB Entry DOI: 10.7270/Q2319XRB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase HCK (Homo sapiens (Human))	BDBM50156124 (CHEMBL3781528) Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCc2ccccn2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C32H33N5O2/c1-22-12-14-24(15-13-22)37-30(21-29(36-37)32(2,3)4)35-31(38)34-27-16-17-28(26-11-6-5-10-25(26)27)39-20-18-23-9-7-8-19-33-23/h5-17,19,21H,18,20H2,1-4H3,(H2,34,35,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sygnature Discovery Limited Curated by ChEMBL					Assay Description Inhibition of HCK (unknown origin) preincubated for 2 hrs followed by FRET peptide addition measured after 1 hr by Z-LYTE assay				J Med Chem 59: 1727-46 (2016) BindingDB Entry DOI: 10.7270/Q2319XRB
					More data for this Ligand-Target Pair