BDBM50157537 CHEMBL3786005

SMILES: COCCOc1cnc2ccn([C@H](C)c3nnc4ccc(cn34)-c3cnn(C)c3)c(=O)c2c1

InChI Key: InChIKey=MVLDGYLKKKETQP-OAHLLOKOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50157537   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50157537 (CHEMBL3786005) Show SMILES COCCOc1cnc2ccn([C@H](C)c3nnc4ccc(cn34)-c3cnn(C)c3)c(=O)c2c1 |r| Show InChI InChI=1S/C23H23N7O3/c1-15(22-27-26-21-5-4-16(14-30(21)22)17-11-25-28(2)13-17)29-7-6-20-19(23(29)31)10-18(12-24-20)33-9-8-32-3/h4-7,10-15H,8-9H2,1-3H3/t15-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of HGF-mediated MET autophosphorylation in human PC3 cells preincubated for 1 hr followed by stimulation with human HGF measured after 10 ...				J Med Chem 59: 2328-42 (2016) BindingDB Entry DOI: 10.7270/Q2SN0BVN
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50157537 (CHEMBL3786005) Show SMILES COCCOc1cnc2ccn([C@H](C)c3nnc4ccc(cn34)-c3cnn(C)c3)c(=O)c2c1 |r| Show InChI InChI=1S/C23H23N7O3/c1-15(22-27-26-21-5-4-16(14-30(21)22)17-11-25-28(2)13-17)29-7-6-20-19(23(29)31)10-18(12-24-20)33-9-8-32-3/h4-7,10-15H,8-9H2,1-3H3/t15-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f...				J Med Chem 59: 2328-42 (2016) BindingDB Entry DOI: 10.7270/Q2SN0BVN
					More data for this Ligand-Target Pair