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SMILES: Clc1cccc(COC(=O)Nc2ccc3CC4CCC(Cc3c2)C4NS(=O)(=O)c2ccccc2)c1

InChI Key: InChIKey=AMBNQJOUORUGOZ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50157970   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2


(Homo sapiens (Human))		BDBM50157970
PNG
((13-Benzenesulfonylamino-tricyclo[8.2.1.0*3,8*]tri...)
Show SMILES Clc1cccc(COC(=O)Nc2ccc3CC4CCC(Cc3c2)C4NS(=O)(=O)c2ccccc2)c1 |TLB:13:14:23:17.18,22:21:23:17.18,THB:24:23:21.14.20.15:17.18|
Show InChI InChI=1S/C27H27ClN2O4S/c28-23-6-4-5-18(13-23)17-34-27(31)29-24-12-11-19-14-20-9-10-21(15-22(19)16-24)26(20)30-35(32,33)25-7-2-1-3-8-25/h1-8,11-13,16,20-21,26,30H,9-10,14-15,17H2,(H,29,31)
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Similars
Article
PubMed
n/an/a 412n/an/an/an/an/an/a



Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against Gamma-secretase in whole cell inhibition assay using SH-SY5Y cells

Bioorg Med Chem Lett 15: 373-8 (2004)


Article DOI: 10.1016/j.bmcl.2004.10.062
BindingDB Entry DOI: 10.7270/Q2445KZQ
More data for this
Ligand-Target Pair