BDBM50160284 CHEMBL3785379
SMILES: Fc1ccc(cc1)[C@@H]1[C@H](N(C2CCN(CC2)C(=O)n2cncn2)C1=O)c1ccc2OCOc2c1
InChI Key: InChIKey=XRIROGBLGLPXQI-FGZHOGPDSA-N
Data: 10 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM50160284 (CHEMBL3785379) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 4.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Siena Curated by ChEMBL | Assay Description Inhibition of recombinant C-terminal His-tagged human FAAH expressed in sf21 cells using N-arachidonoyl-[14C]-ethanolamine as substrate assessed as r... | J Med Chem 59: 2612-32 (2016) BindingDB Entry DOI: 10.7270/Q21R6SC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 (Homo sapiens (Human)) | BDBM50160284 (CHEMBL3785379) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.88E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Siena Curated by ChEMBL | Assay Description Inhibition of recombinant C-terminal His-tagged human FAAH expressed in sf21 cells using N-arachidonoyl-[14C]-ethanolamine as substrate assessed as r... | J Med Chem 59: 2612-32 (2016) BindingDB Entry DOI: 10.7270/Q21R6SC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoglyceride lipase (MGL) (Rattus norvegicus (Rat)) | BDBM50160284 (CHEMBL3785379) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Siena Curated by ChEMBL | Assay Description Inhibition of rat MAGL | J Med Chem 59: 2612-32 (2016) BindingDB Entry DOI: 10.7270/Q21R6SC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoglyceride lipase (Homo sapiens (Human)) | BDBM50160284 (CHEMBL3785379) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Siena Curated by ChEMBL | Assay Description Inhibition of recombinant C-terminal His6-tagged human MAGL expressed in Escherichia coli using 2-arachidonoyl-[3H]-glycerol as substrate incubated f... | J Med Chem 59: 2612-32 (2016) BindingDB Entry DOI: 10.7270/Q21R6SC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoglyceride lipase (MGL) (Rattus norvegicus (Rat)) | BDBM50160284 (CHEMBL3785379) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Siena Curated by ChEMBL | Assay Description Inhibition of MAGL in rat brain membranes preincubated for 20 mins followed by fluorophosphonate-rhodamine addition measured after 30 mins by competi... | J Med Chem 59: 2612-32 (2016) BindingDB Entry DOI: 10.7270/Q21R6SC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50160284 (CHEMBL3785379) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Siena Curated by ChEMBL | Assay Description Displacement of [3H]-CP-55940 from human recombinant CB1 receptor expressed in HEK293 cells after 90 mins | J Med Chem 59: 2612-32 (2016) BindingDB Entry DOI: 10.7270/Q21R6SC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 2 (Homo sapiens (Human)) | BDBM50160284 (CHEMBL3785379) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Siena Curated by ChEMBL | Assay Description Displacement of [3H]-CP-55940 from human recombinant CB2 receptor expressed in HEK293 cells after 90 mins | J Med Chem 59: 2612-32 (2016) BindingDB Entry DOI: 10.7270/Q21R6SC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoglyceride lipase (Homo sapiens (Human)) | BDBM50160284 (CHEMBL3785379) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 196 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Siena Curated by ChEMBL | Assay Description Inhibition of recombinant C-terminal His6-tagged human MAGL expressed in Escherichia coli using 2-arachidonoyl-[3H]-glycerol as substrate preincubate... | J Med Chem 59: 2612-32 (2016) BindingDB Entry DOI: 10.7270/Q21R6SC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoglyceride lipase (Homo sapiens (Human)) | BDBM50160284 (CHEMBL3785379) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Siena Curated by ChEMBL | Assay Description Inhibition of recombinant C-terminal His6-tagged human MAGL expressed in Escherichia coli using 2-arachidonoyl-[3H]-glycerol as substrate preincubate... | J Med Chem 59: 2612-32 (2016) BindingDB Entry DOI: 10.7270/Q21R6SC7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoglyceride lipase (Homo sapiens (Human)) | BDBM50160284 (CHEMBL3785379) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Siena Curated by ChEMBL | Assay Description Inhibition of recombinant C-terminal His6-tagged human MAGL expressed in Escherichia coli using 2-arachidonoyl-[3H]-glycerol as substrate incubated f... | J Med Chem 59: 2612-32 (2016) BindingDB Entry DOI: 10.7270/Q21R6SC7 | |||||||||||
More data for this Ligand-Target Pair |