BDBM50163001 3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(1-phenyl-1H-indol-3-yl)-pyrrole-2,5-dione::CHEMBL366668

SMILES: CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c2cn(-c3ccccc3)c3ccccc23)c2ccccc12

InChI Key: InChIKey=JXDMRMYIFDKNHE-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50163001   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM50163001 (3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...) Show SMILES CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c2cn(-c3ccccc3)c3ccccc23)c2ccccc12 |t:9| Show InChI InChI=1S/C30H27N5O2/c1-33(2)17-10-18-35-25-16-9-7-14-22(25)28(32-35)27-26(29(36)31-30(27)37)23-19-34(20-11-4-3-5-12-20)24-15-8-6-13-21(23)24/h3-9,11-16,19H,10,17-18H2,1-2H3,(H,31,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of human Protein kinase C beta 1 using [gamma-33P]-ATP				J Med Chem 48: 1725-8 (2005) Article DOI: 10.1021/jm049478u BindingDB Entry DOI: 10.7270/Q2765DVX
					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50163001 (3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...) Show SMILES CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c2cn(-c3ccccc3)c3ccccc23)c2ccccc12 |t:9| Show InChI InChI=1S/C30H27N5O2/c1-33(2)17-10-18-35-25-16-9-7-14-22(25)28(32-35)27-26(29(36)31-30(27)37)23-19-34(20-11-4-3-5-12-20)24-15-8-6-13-21(23)24/h3-9,11-16,19H,10,17-18H2,1-2H3,(H,31,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of human Protein kinase C alpha using [gamma-33P]-ATP				J Med Chem 48: 1725-8 (2005) Article DOI: 10.1021/jm049478u BindingDB Entry DOI: 10.7270/Q2765DVX
					More data for this Ligand-Target Pair
Protein kinase C, gamma (Homo sapiens (Human))	BDBM50163001 (3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...) Show SMILES CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c2cn(-c3ccccc3)c3ccccc23)c2ccccc12 |t:9| Show InChI InChI=1S/C30H27N5O2/c1-33(2)17-10-18-35-25-16-9-7-14-22(25)28(32-35)27-26(29(36)31-30(27)37)23-19-34(20-11-4-3-5-12-20)24-15-8-6-13-21(23)24/h3-9,11-16,19H,10,17-18H2,1-2H3,(H,31,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of human Protein kinase C gamma using [gamma-33P]-ATP				J Med Chem 48: 1725-8 (2005) Article DOI: 10.1021/jm049478u BindingDB Entry DOI: 10.7270/Q2765DVX
					More data for this Ligand-Target Pair
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM50163001 (3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...) Show SMILES CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c2cn(-c3ccccc3)c3ccccc23)c2ccccc12 |t:9| Show InChI InChI=1S/C30H27N5O2/c1-33(2)17-10-18-35-25-16-9-7-14-22(25)28(32-35)27-26(29(36)31-30(27)37)23-19-34(20-11-4-3-5-12-20)24-15-8-6-13-21(23)24/h3-9,11-16,19H,10,17-18H2,1-2H3,(H,31,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of IL-8 release by HEK293 cells expressing PKC-beta2				J Med Chem 48: 1725-8 (2005) Article DOI: 10.1021/jm049478u BindingDB Entry DOI: 10.7270/Q2765DVX
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50163001 (3-[1-(3-Dimethylamino-propyl)-1H-indazol-3-yl]-4-(...) Show SMILES CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c2cn(-c3ccccc3)c3ccccc23)c2ccccc12 |t:9| Show InChI InChI=1S/C30H27N5O2/c1-33(2)17-10-18-35-25-16-9-7-14-22(25)28(32-35)27-26(29(36)31-30(27)37)23-19-34(20-11-4-3-5-12-20)24-15-8-6-13-21(23)24/h3-9,11-16,19H,10,17-18H2,1-2H3,(H,31,36,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of rabbit Glycogen synthase kinase-3 beta				J Med Chem 48: 1725-8 (2005) Article DOI: 10.1021/jm049478u BindingDB Entry DOI: 10.7270/Q2765DVX
					More data for this Ligand-Target Pair