BDBM50163383 CHEMBL3793956

SMILES: Cc1cc(cc(C)c1NC(=O)c1nc(ccc1C)N1CCCC(CO)C1)C(O)=O

InChI Key: InChIKey=FRRVNUMGKQGXOM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50163383   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50163383 (CHEMBL3793956) Show SMILES Cc1cc(cc(C)c1NC(=O)c1nc(ccc1C)N1CCCC(CO)C1)C(O)=O Show InChI InChI=1S/C22H27N3O4/c1-13-6-7-18(25-8-4-5-16(11-25)12-26)23-20(13)21(27)24-19-14(2)9-17(22(28)29)10-15(19)3/h6-7,9-10,16,26H,4-5,8,11-12H2,1-3H3,(H,24,27)(H,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity against EP4 in human whole blood assessed as reversal of PGE2-mediated suppression of LPS-induced TNF-alpha production preincubat...				Bioorg Med Chem Lett 26: 2303-7 (2016) BindingDB Entry DOI: 10.7270/Q22F7QBJ
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50163383 (CHEMBL3793956) Show SMILES Cc1cc(cc(C)c1NC(=O)c1nc(ccc1C)N1CCCC(CO)C1)C(O)=O Show InChI InChI=1S/C22H27N3O4/c1-13-6-7-18(25-8-4-5-16(11-25)12-26)23-20(13)21(27)24-19-14(2)9-17(22(28)29)10-15(19)3/h6-7,9-10,16,26H,4-5,8,11-12H2,1-3H3,(H,24,27)(H,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by...				Bioorg Med Chem Lett 26: 2303-7 (2016) BindingDB Entry DOI: 10.7270/Q22F7QBJ
					More data for this Ligand-Target Pair