BDBM50164234 1-Cyclopentanesulfonyl-6-[2-(2,6-difluoro-phenyl)-5-phenyl-3H-imidazol-4-yl]-1H-benzoimidazol-2-ylamine; Bismesylate salt::CHEMBL193247

SMILES: Nc1nc2ccc(cc2n1S(=O)(=O)C1CCCC1)-c1[nH]c(nc1-c1ccccc1)-c1c(F)cccc1F

InChI Key: InChIKey=DMVLGJOBKSHMDG-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50164234   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50164234 (1-Cyclopentanesulfonyl-6-[2-(2,6-difluoro-phenyl)-...) Show SMILES Nc1nc2ccc(cc2n1S(=O)(=O)C1CCCC1)-c1[nH]c(nc1-c1ccccc1)-c1c(F)cccc1F Show InChI InChI=1S/C27H23F2N5O2S/c28-19-11-6-12-20(29)23(19)26-32-24(16-7-2-1-3-8-16)25(33-26)17-13-14-21-22(15-17)34(27(30)31-21)37(35,36)18-9-4-5-10-18/h1-3,6-8,11-15,18H,4-5,9-10H2,(H2,30,31)(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Co. Curated by ChEMBL					Assay Description In vitro inhibitory concentration against Cytochrome P450 3A4				J Med Chem 48: 2270-3 (2005) Article DOI: 10.1021/jm048978k BindingDB Entry DOI: 10.7270/Q2M90869
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50164234 (1-Cyclopentanesulfonyl-6-[2-(2,6-difluoro-phenyl)-...) Show SMILES Nc1nc2ccc(cc2n1S(=O)(=O)C1CCCC1)-c1[nH]c(nc1-c1ccccc1)-c1c(F)cccc1F Show InChI InChI=1S/C27H23F2N5O2S/c28-19-11-6-12-20(29)23(19)26-32-24(16-7-2-1-3-8-16)25(33-26)17-13-14-21-22(15-17)34(27(30)31-21)37(35,36)18-9-4-5-10-18/h1-3,6-8,11-15,18H,4-5,9-10H2,(H2,30,31)(H,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19.9	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Co. Curated by ChEMBL					Assay Description Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptide				J Med Chem 48: 2270-3 (2005) Article DOI: 10.1021/jm048978k BindingDB Entry DOI: 10.7270/Q2M90869
					More data for this Ligand-Target Pair