BDBM50164236 6-[2-tert-Butyl-5-(2,4-difluoro-phenyl)-3H-imidazol-4-yl]-1-(propane-2-sulfonyl)-1H-benzoimidazol-2-ylamine; compound with methanesulfonic acid::CHEMBL363831::CHEMBL404377
SMILES: CC(C)S(=O)(=O)n1c(N)nc2ccc(cc12)-c1[nH]c(nc1-c1ccc(F)cc1F)C(C)(C)C
InChI Key: InChIKey=KIPJKVFPFLSCTH-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM50164236 (6-[2-tert-Butyl-5-(2,4-difluoro-phenyl)-3H-imidazo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Co. Curated by ChEMBL | Assay Description Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptide | J Med Chem 48: 2270-3 (2005) Article DOI: 10.1021/jm048978k BindingDB Entry DOI: 10.7270/Q2M90869 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase p38 (Mus musculus (mouse)) | BDBM50164236 (6-[2-tert-Butyl-5-(2,4-difluoro-phenyl)-3H-imidazo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 26.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Co. Curated by ChEMBL | Assay Description Inhibition of mouse p38alpha in anisomycin-stimulated RAW 264.7 cells by ELISA | Bioorg Med Chem Lett 18: 179-83 (2008) Article DOI: 10.1016/j.bmcl.2007.10.106 BindingDB Entry DOI: 10.7270/Q2R78G31 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM50164236 (6-[2-tert-Butyl-5-(2,4-difluoro-phenyl)-3H-imidazo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Co. Curated by ChEMBL | Assay Description Inhibition of human recombinant p38alpha | Bioorg Med Chem Lett 18: 179-83 (2008) Article DOI: 10.1016/j.bmcl.2007.10.106 BindingDB Entry DOI: 10.7270/Q2R78G31 | |||||||||||
More data for this Ligand-Target Pair |