BDBM50164255 1-[(1S,2R,5S)-5-(2-Cyano-phenyl)-bicyclo[3.1.0]hex-2-yl]-3-(4-fluoro-3-trifluoromethyl-phenyl)-1-[2-((R)-3-hydroxy-pyrrolidin-1-yl)-ethyl]-urea::CHEMBL364500
SMILES: O[C@@H]1CCN(CCN([C@@H]2CC[C@@]3(C[C@H]23)c2ccccc2C#N)C(=O)Nc2ccc(F)c(c2)C(F)(F)F)C1
InChI Key: InChIKey=ZXXLRCVKQUILPH-JKWAAVNQSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Melanin-concentrating hormone receptor (Homo sapiens (Human)) | BDBM50164255 (1-[(1S,2R,5S)-5-(2-Cyano-phenyl)-bicyclo[3.1.0]hex...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 7.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute Curated by ChEMBL | Assay Description Inhibition constant for human Melanin concentrating hormone receptor 1 | J Med Chem 48: 2274-7 (2005) Article DOI: 10.1021/jm049035q BindingDB Entry DOI: 10.7270/Q2GH9HG1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GPR145 (Homo sapiens (Human)) | BDBM50164255 (1-[(1S,2R,5S)-5-(2-Cyano-phenyl)-bicyclo[3.1.0]hex...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute Curated by ChEMBL | Assay Description Inhibition constant for human Melanin concentrating hormone receptor 2 | J Med Chem 48: 2274-7 (2005) Article DOI: 10.1021/jm049035q BindingDB Entry DOI: 10.7270/Q2GH9HG1 | |||||||||||
More data for this Ligand-Target Pair |