BindingDB PrimarySearch

BDBM50166287 (RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetrazolyl)-4-isoxazolyl]propionic acid::2-Amino-3-[3-hydroxy-5-(2-isopropyl-2H-tetrazol-5-yl)-isoxazol-4-yl]-propionic acid::2-amino-3-(3-hydroxy-5-(2-isopropyl-2H-tetrazol-5-yl)isoxazol-4-yl)propanoic acid::CHEMBL193087

SMILES: CC(C)n1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O

InChI Key: InChIKey=JLSSNIZWTYHLRK-UHFFFAOYSA-N

Data: 12 KI 5 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50166287
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Glutamate receptor ionotropic, AMPA 4 (Rattus norvegicus)	BDBM50166287 ((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]AMPA from rat recombinant GluR4 expressed in Sf9 cells				J Med Chem 50: 2408-14 (2007) Article DOI: 10.1021/jm061439q BindingDB Entry DOI: 10.7270/Q2DZ0809
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, AMPA 2 (Rattus norvegicus)	BDBM50166287 ((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]AMPA from rat recombinant GluR2 expressed in Sf9 cells				J Med Chem 50: 2408-14 (2007) Article DOI: 10.1021/jm061439q BindingDB Entry DOI: 10.7270/Q2DZ0809
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
GRIA3 (RAT)	BDBM50166287 ((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]AMPA from rat recombinant GluR3 expressed in Sf9 cells				J Med Chem 50: 2408-14 (2007) Article DOI: 10.1021/jm061439q BindingDB Entry DOI: 10.7270/Q2DZ0809
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor 1 (Rattus norvegicus (Rat))	BDBM50166287 ((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]AMPA from rat recombinant GluR1 expressed in Sf9 cells				J Med Chem 50: 2408-14 (2007) Article DOI: 10.1021/jm061439q BindingDB Entry DOI: 10.7270/Q2DZ0809
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM50166287 ((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	31	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]SYM 2081 from rat recombinant GluR5 expressed in Sf9 cells				J Med Chem 50: 2408-14 (2007) Article DOI: 10.1021/jm061439q BindingDB Entry DOI: 10.7270/Q2DZ0809
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5 (Rattus norvegicus)	BDBM50166287 ((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]KA from rat recombinant GluR6 expressed in Sf9 cells				J Med Chem 50: 2408-14 (2007) Article DOI: 10.1021/jm061439q BindingDB Entry DOI: 10.7270/Q2DZ0809
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM50166287 ((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.35E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Binding affinity for ionotropic Glutamate receptor AMPA 4 expressed in Sf9 cells				J Med Chem 48: 3438-42 (2005) Article DOI: 10.1021/jm050014l BindingDB Entry DOI: 10.7270/Q2H70FBJ
					More data for this Ligand-Target Pair
GRIA2 (Homo sapiens (Human))	BDBM50166287 ((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.93E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Binding affinity for ionotropic Glutamate receptor AMPA 2 expressed in Sf9 cells				J Med Chem 48: 3438-42 (2005) Article DOI: 10.1021/jm050014l BindingDB Entry DOI: 10.7270/Q2H70FBJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM50166287 ((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.71E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Binding affinity for ionotropic Glutamate receptor AMPA 3 expressed in Sf9 cells				J Med Chem 48: 3438-42 (2005) Article DOI: 10.1021/jm050014l BindingDB Entry DOI: 10.7270/Q2H70FBJ
					More data for this Ligand-Target Pair
GRIA1 (Homo sapiens (Human))	BDBM50166287 ((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Binding affinity for ionotropic Glutamate receptor AMPA 1 expressed in Sf9 cells				J Med Chem 48: 3438-42 (2005) Article DOI: 10.1021/jm050014l BindingDB Entry DOI: 10.7270/Q2H70FBJ
					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM50166287 ((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.42E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Binding affinity for kainate Glutamate receptor GluR5 expressed in Sf9 cells				J Med Chem 48: 3438-42 (2005) Article DOI: 10.1021/jm050014l BindingDB Entry DOI: 10.7270/Q2H70FBJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2 (Homo sapiens (Human))	BDBM50166287 ((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description Binding affinity for kainate Glutamate receptor GluR6 expressed in Sf9 cells				J Med Chem 48: 3438-42 (2005) Article DOI: 10.1021/jm050014l BindingDB Entry DOI: 10.7270/Q2H70FBJ
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM50166287 ((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.60E+5	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at GluR4 expressed in HEK293 cells by Fluo-4/Ca2+ assay				J Med Chem 50: 4177-85 (2007) Article DOI: 10.1021/jm070532r BindingDB Entry DOI: 10.7270/Q29P32F3
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM50166287 ((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.00E+5	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at GluR3 expressed in HEK293 cells by Fluo-4/Ca2+ assay				J Med Chem 50: 4177-85 (2007) Article DOI: 10.1021/jm070532r BindingDB Entry DOI: 10.7270/Q29P32F3
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
GRIA2 (Homo sapiens (Human))	BDBM50166287 ((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+6	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at GluR2Q expressed in HEK293 cells by Fluo-4/Ca2+ assay				J Med Chem 50: 4177-85 (2007) Article DOI: 10.1021/jm070532r BindingDB Entry DOI: 10.7270/Q29P32F3
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
GRIA1 (Homo sapiens (Human))	BDBM50166287 ((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.50E+5	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at GluR1 expressed in HEK293 cells by Fluo-4/Ca2+ assay				J Med Chem 50: 4177-85 (2007) Article DOI: 10.1021/jm070532r BindingDB Entry DOI: 10.7270/Q29P32F3
University of Copenhagen Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate (Rattus norvegicus)	BDBM50166287 ((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.10E+4	n/a	n/a	n/a	n/a
The Danish University of Pharmaceutical Sciences Curated by ChEMBL					Assay Description In vitro activity of the compound at Ionotropic glutamate receptor using cortical wedge assays in rat brain synaptosoma				J Med Chem 48: 3438-42 (2005) Article DOI: 10.1021/jm050014l BindingDB Entry DOI: 10.7270/Q2H70FBJ
					More data for this Ligand-Target Pair