BDBM50166456 (R)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-amino-2-phenylethyl)-5-phenylpyrimidine-2,4(1H,3H)-dione::3-((R)-2-Amino-2-phenyl-ethyl)-1-(2-fluoro-6-trifluoromethyl-benzyl)-5-phenyl-1H-pyrimidine-2,4-dione::CHEMBL365985

SMILES: N[C@@H](Cn1c(=O)c(cn(Cc2c(F)cccc2C(F)(F)F)c1=O)-c1ccccc1)c1ccccc1

InChI Key: InChIKey=AVWXVFNJXMOFEK-QHCPKHFHSA-N

Data: 2 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50166456   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gonadotropin releasing hormone 1 (GnRHR1) (Homo sapiens (Human))	BDBM50166456 ((R)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-am...) Show SMILES N[C@@H](Cn1c(=O)c(cn(Cc2c(F)cccc2C(F)(F)F)c1=O)-c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C26H21F4N3O2/c27-22-13-7-12-21(26(28,29)30)20(22)15-32-14-19(17-8-3-1-4-9-17)24(34)33(25(32)35)16-23(31)18-10-5-2-6-11-18/h1-14,23H,15-16,31H2/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity towards human gonadotropin-releasing hormone receptor (GNRHR) using GnRH peptide as radioligand				Bioorg Med Chem Lett 15: 2519-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.057 BindingDB Entry DOI: 10.7270/Q2M044ZX
					More data for this Ligand-Target Pair
Gonadotropin releasing hormone 1 (GnRHR1) (Homo sapiens (Human))	BDBM50166456 ((R)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-am...) Show SMILES N[C@@H](Cn1c(=O)c(cn(Cc2c(F)cccc2C(F)(F)F)c1=O)-c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C26H21F4N3O2/c27-22-13-7-12-21(26(28,29)30)20(22)15-32-14-19(17-8-3-1-4-9-17)24(34)33(25(32)35)16-23(31)18-10-5-2-6-11-18/h1-14,23H,15-16,31H2/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity to human GnRHR				Bioorg Med Chem Lett 18: 3301-5 (2008) Article DOI: 10.1016/j.bmcl.2008.04.036 BindingDB Entry DOI: 10.7270/Q2JD4WKM
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50166456 ((R)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-am...) Show SMILES N[C@@H](Cn1c(=O)c(cn(Cc2c(F)cccc2C(F)(F)F)c1=O)-c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C26H21F4N3O2/c27-22-13-7-12-21(26(28,29)30)20(22)15-32-14-19(17-8-3-1-4-9-17)24(34)33(25(32)35)16-23(31)18-10-5-2-6-11-18/h1-14,23H,15-16,31H2/t23-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibition of CYP3A4 (unknown origin)				Bioorg Med Chem Lett 18: 3301-5 (2008) Article DOI: 10.1016/j.bmcl.2008.04.036 BindingDB Entry DOI: 10.7270/Q2JD4WKM
					More data for this Ligand-Target Pair