BDBM50168643 3-Amino-N-{(R)-1-(2,4-dichloro-benzyl)-2-oxo-2-[4-(1-{[(thiophen-2-ylmethyl)-amino]-methyl}-cyclohexyl)-piperazin-1-yl]-ethyl}-propionamide::CHEMBL365465
SMILES: NCCC(=O)N[C@H](Cc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)C1(CNCc2cccs2)CCCCC1
InChI Key: InChIKey=XQPGJXQZZJHBDT-RUZDIDTESA-N
Data: 4 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Melanocortin receptor 4 (Homo sapiens (Human)) | BDBM50168643 (3-Amino-N-{(R)-1-(2,4-dichloro-benzyl)-2-oxo-2-[4-...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description Inhibition of [125I]-AgRP(83132) (radioligand) binding to the hMC4R stably expressed in HEK293 cells | Bioorg Med Chem Lett 15: 3434-8 (2005) Article DOI: 10.1016/j.bmcl.2005.05.017 BindingDB Entry DOI: 10.7270/Q2PG1R8Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 5 (MC5R) (Homo sapiens (Human)) | BDBM50168643 (3-Amino-N-{(R)-1-(2,4-dichloro-benzyl)-2-oxo-2-[4-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC5R stably expressed in HEK293 cells | Bioorg Med Chem Lett 15: 3434-8 (2005) Article DOI: 10.1016/j.bmcl.2005.05.017 BindingDB Entry DOI: 10.7270/Q2PG1R8Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocortin receptor 3 (Homo sapiens (Human)) | BDBM50168643 (3-Amino-N-{(R)-1-(2,4-dichloro-benzyl)-2-oxo-2-[4-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description Inhibition of [125I]-NDP-MSH (radioligand) binding to the human MC3R stably expressed in HEK293 cells | Bioorg Med Chem Lett 15: 3434-8 (2005) Article DOI: 10.1016/j.bmcl.2005.05.017 BindingDB Entry DOI: 10.7270/Q2PG1R8Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melanocyte-stimulating hormone receptor (Homo sapiens (Human)) | BDBM50168643 (3-Amino-N-{(R)-1-(2,4-dichloro-benzyl)-2-oxo-2-[4-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc. Curated by ChEMBL | Assay Description Inhibition of [125I]-NDP-MSH (radioligand) binding to human MC1R at 10 um concentration stably expressed in HEK293 cells | Bioorg Med Chem Lett 15: 3434-8 (2005) Article DOI: 10.1016/j.bmcl.2005.05.017 BindingDB Entry DOI: 10.7270/Q2PG1R8Q | |||||||||||
More data for this Ligand-Target Pair |