BDBM50170210 CHEMBL367148::[4-(4-Trifluoromethoxy-phenyl)-thiophene-2-carbonyl]-carbamic acid 4-methyl-benzyl ester

SMILES: Cc1ccc(COC(=O)NC(=O)c2cc(cs2)-c2ccc(OC(F)(F)F)cc2)cc1

InChI Key: InChIKey=FMBCNTQGGGDHCQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50170210   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Matrix metalloproteinase-12 (MMP12) (Homo sapiens (Human))	BDBM50170210 (CHEMBL367148 | [4-(4-Trifluoromethoxy-phenyl)-thio...) Show SMILES Cc1ccc(COC(=O)NC(=O)c2cc(cs2)-c2ccc(OC(F)(F)F)cc2)cc1 Show InChI InChI=1S/C21H16F3NO4S/c1-13-2-4-14(5-3-13)11-28-20(27)25-19(26)18-10-16(12-30-18)15-6-8-17(9-7-15)29-21(22,23)24/h2-10,12H,11H2,1H3,(H,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximate				Bioorg Med Chem Lett 15: 3787-90 (2005) Article DOI: 10.1016/j.bmcl.2005.05.079 BindingDB Entry DOI: 10.7270/Q2736QFM
					More data for this Ligand-Target Pair