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SMILES: Clc1cccc(c1Cl)-n1nnc(n1)-c1ccccn1

InChI Key: InChIKey=LISWCCWVQRMQRS-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50174216   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50174216 (2-[2-(2,3-Dichloro-phenyl)-2H-tetrazol-5-yl]-pyrid...) Show SMILES Clc1cccc(c1Cl)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C12H7Cl2N5/c13-8-4-3-6-10(11(8)14)19-17-12(16-18-19)9-5-1-2-7-15-9/h1-7H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	>600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Ability to displace [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from binding to metabotropic glutamate receptor 5 in rat cortical membranes				Bioorg Med Chem Lett 15: 5061-4 (2005) Article DOI: 10.1016/j.bmcl.2005.07.062 BindingDB Entry DOI: 10.7270/Q2GT5MQ0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50174216 (2-[2-(2,3-Dichloro-phenyl)-2H-tetrazol-5-yl]-pyrid...) Show SMILES Clc1cccc(c1Cl)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C12H7Cl2N5/c13-8-4-3-6-10(11(8)14)19-17-12(16-18-19)9-5-1-2-7-15-9/h1-7H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro functional activity measured by changes in cytosolic [Ca2+] concentrations against rat metabotropic glutamate receptor 5				Bioorg Med Chem Lett 15: 5061-4 (2005) Article DOI: 10.1016/j.bmcl.2005.07.062 BindingDB Entry DOI: 10.7270/Q2GT5MQ0
					More data for this Ligand-Target Pair