BDBM50174890 Bu-Apc-DPhe-Arg-2-Nal-Z4-NH2::CHEMBL436296

SMILES: CCCC(=O)N[C@@]1(CC[C@@H](CC1)c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(Cc1ccc2ccccc2c1)C(=O)NCCC(N)=O

InChI Key: InChIKey=GDMWDRLPDNFNGC-TZGZHONCSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50174890   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50174890 (Bu-Apc-DPhe-Arg-2-Nal-Z4-NH2 | CHEMBL436296) Show SMILES CCCC(=O)N[C@@]1(CC[C@@H](CC1)c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(Cc1ccc2ccccc2c1)C(=O)NCCC(N)=O |wU:21.22,32.34,9.12,6.5,wD:6.19,(-7.6,-9.56,;-6.26,-8.8,;-4.94,-9.57,;-3.6,-8.8,;-3.6,-7.26,;-2.27,-9.57,;-.91,-8.8,;.41,-8.04,;.42,-6.51,;-.91,-5.73,;-2.24,-6.5,;-2.25,-8.04,;-.9,-4.21,;.44,-3.44,;.44,-1.9,;-.89,-1.13,;-2.22,-1.9,;-2.22,-3.43,;.41,-9.57,;.41,-11.11,;1.75,-8.8,;3.09,-9.57,;3.09,-11.11,;4.42,-11.89,;4.41,-13.43,;5.74,-14.19,;7.09,-13.43,;7.08,-11.88,;5.75,-11.12,;4.42,-8.8,;4.42,-7.26,;5.76,-9.57,;7.09,-8.8,;7.09,-7.26,;8.43,-6.48,;8.43,-4.94,;9.77,-4.17,;9.77,-2.62,;11.1,-1.85,;8.43,-1.85,;8.43,-9.57,;8.43,-11.11,;9.77,-8.8,;11.1,-9.57,;11.1,-11.11,;12.44,-11.89,;13.77,-11.12,;15.1,-11.89,;15.11,-13.44,;16.44,-14.21,;16.44,-15.75,;15.09,-16.53,;13.76,-15.75,;13.77,-14.2,;12.44,-13.44,;12.44,-8.8,;12.44,-7.26,;13.78,-9.57,;15.11,-8.8,;16.44,-9.56,;17.76,-8.79,;19.09,-9.55,;17.76,-7.25,)| Show InChI InChI=1S/C48H61N9O6/c1-2-12-42(59)57-48(25-22-36(23-26-48)34-15-7-4-8-16-34)46(63)56-40(30-32-13-5-3-6-14-32)45(62)54-38(19-11-27-53-47(50)51)44(61)55-39(43(60)52-28-24-41(49)58)31-33-20-21-35-17-9-10-18-37(35)29-33/h3-10,13-18,20-21,29,36,38-40H,2,11-12,19,22-28,30-31H2,1H3,(H2,49,58)(H,52,60)(H,54,62)(H,55,61)(H,56,63)(H,57,59)(H4,50,51,53)/t36-,38-,39?,40+,48+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	90	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Agonist activity in HEK293 cells transfected with human MC4R by cAMP accumulation				Bioorg Med Chem Lett 15: 5504-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.083 BindingDB Entry DOI: 10.7270/Q2MC8ZK7
					More data for this Ligand-Target Pair