BDBM50175661 (R)-(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)piperazin-1-yl)(pyrrolidin-2-yl)methanone::CHEMBL200465

SMILES: Clc1ccc(CNc2ccnc(n2)N2CCN(CC2)C(=O)[C@H]2CCCN2)c(Cl)c1

InChI Key: InChIKey=KRHPKCNOPOMSIP-QGZVFWFLSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50175661   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-C chemokine receptor type 4 (CCR4) (Homo sapiens (Human))	BDBM50175661 ((R)-(4-(4-(2,4-dichlorobenzylamino)pyrimidin-2-yl)...) Show SMILES Clc1ccc(CNc2ccnc(n2)N2CCN(CC2)C(=O)[C@H]2CCCN2)c(Cl)c1 Show InChI InChI=1S/C20H24Cl2N6O/c21-15-4-3-14(16(22)12-15)13-25-18-5-7-24-20(26-18)28-10-8-27(9-11-28)19(29)17-2-1-6-23-17/h3-5,7,12,17,23H,1-2,6,8-11,13H2,(H,24,25,26)/t17-/m1/s1	UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]TARC from human CCR4 receptor transfected in HEK293 cells				Bioorg Med Chem Lett 16: 204-7 (2005) Article DOI: 10.1016/j.bmcl.2005.09.022 BindingDB Entry DOI: 10.7270/Q2GH9HHG
					More data for this Ligand-Target Pair