null

SMILES: Clc1ccc2C(N3CCN(C(C3)C(=O)NCCc3cnc[nH]3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1

InChI Key: InChIKey=HQHGMTIPVQADEA-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50177258   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177258 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCCc3cnc[nH]3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C31H37BrClN7O2/c32-22-14-21-7-6-20-15-23(33)8-9-26(20)29(28(21)36-16-22)39-12-13-40(31(42)38-24-4-2-1-3-5-24)27(18-39)30(41)35-11-10-25-17-34-19-37-25/h8-9,14-17,19,24,27,29H,1-7,10-13,18H2,(H,34,37)(H,35,41)(H,38,42)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against Ha-Ras processing in COS7 cells				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta (Homo sapiens (Human))	BDBM50177258 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCCc3cnc[nH]3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C31H37BrClN7O2/c32-22-14-21-7-6-20-15-23(33)8-9-26(20)29(28(21)36-16-22)39-12-13-40(31(42)38-24-4-2-1-3-5-24)27(18-39)30(41)35-11-10-25-17-34-19-37-25/h8-9,14-17,19,24,27,29H,1-7,10-13,18H2,(H,34,37)(H,35,41)(H,38,42)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair