BDBM50177263 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperazine-1,2-dicarboxylicacid 1-cyclohexylamide 2-[(pyridin-3-ylmethyl)-amide]::CHEMBL372343

SMILES: Clc1ccc2C(N3CCN(C(C3)C(=O)NCc3cccnc3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1

InChI Key: InChIKey=NSYTZIOXSOGJFP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50177263   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM50177263 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCc3cccnc3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C32H36BrClN6O2/c33-24-15-23-9-8-22-16-25(34)10-11-27(22)30(29(23)36-19-24)39-13-14-40(32(42)38-26-6-2-1-3-7-26)28(20-39)31(41)37-18-21-5-4-12-35-17-21/h4-5,10-12,15-17,19,26,28,30H,1-3,6-9,13-14,18,20H2,(H,37,41)(H,38,42)	PDB KEGG GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against Ha-Ras processing in COS7 cells				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM50177263 (4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cycl...) Show SMILES Clc1ccc2C(N3CCN(C(C3)C(=O)NCc3cccnc3)C(=O)NC3CCCCC3)c3ncc(Br)cc3CCc2c1 Show InChI InChI=1S/C32H36BrClN6O2/c33-24-15-23-9-8-22-16-25(34)10-11-27(22)30(29(23)36-19-24)39-13-14-40(32(42)38-26-6-2-1-3-7-26)28(20-39)31(41)37-18-21-5-4-12-35-17-21/h4-5,10-12,15-17,19,26,28,30H,1-3,6-9,13-14,18,20H2,(H,37,41)(H,38,42)	PDB KEGG GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
Princ Curated by ChEMBL					Assay Description Inhibitory activity against farnesyltransferase quantified by SPA assay				Bioorg Med Chem Lett 16: 507-11 (2005) Article DOI: 10.1016/j.bmcl.2005.10.070 BindingDB Entry DOI: 10.7270/Q2M0450S
					More data for this Ligand-Target Pair