BDBM50177969 2-cyano-N-{2-[2-cyano-3-(4-methoxyphenyl)acryloylamino]ethyl}-3-(4-methoxyphenyl)acrylamide::CHEMBL370851

SMILES: COc1ccc(\C=C(/C#N)C(=O)NCCNC(=O)C(=C\c2ccc(OC)cc2)\C#N)cc1

InChI Key: InChIKey=QLBWMTGZXNXYKJ-IWGRKNQJSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50177969   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dynamin-1 (Homo sapiens (Human))	BDBM50177969 (2-cyano-N-{2-[2-cyano-3-(4-methoxyphenyl)acryloyla...) Show SMILES COc1ccc(\C=C(/C#N)C(=O)NCCNC(=O)C(=C\c2ccc(OC)cc2)\C#N)cc1 Show InChI InChI=1S/C24H22N4O4/c1-31-21-7-3-17(4-8-21)13-19(15-25)23(29)27-11-12-28-24(30)20(16-26)14-18-5-9-22(32-2)10-6-18/h3-10,13-14H,11-12H2,1-2H3,(H,27,29)(H,28,30)/b19-13+,20-14+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair