BDBM50179853 5'-(7-ethyl-8-oxo-7,8-dihydroimidazo[1,2-a]pyrazin-3-yl)-2',4-difluoro-1,1'-biphenyl-2-carbonitrile::CHEMBL206587
SMILES: CCn1ccn2c(cnc2c1=O)-c1ccc(F)c(c1)-c1ccc(F)cc1C#N
InChI Key: InChIKey=RYKBQSSZEXHGJL-UHFFFAOYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GABA receptor alpha-5/beta-3/gamma-2 subunit (Homo sapiens (Human)) | BDBM50179853 (5'-(7-ethyl-8-oxo-7,8-dihydroimidazo[1,2-a]pyrazin...) | PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck, Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]Ro15-1788 from human recombinant GABA-Aalpha5 receptor plus beta3gamma2 | Bioorg Med Chem Lett 16: 1582-5 (2006) Article DOI: 10.1016/j.bmcl.2005.12.027 BindingDB Entry DOI: 10.7270/Q25B022B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GABA receptor alpha-1/beta-3/gamma-2 subunit (Homo sapiens (Human)) | BDBM50179853 (5'-(7-ethyl-8-oxo-7,8-dihydroimidazo[1,2-a]pyrazin...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck, Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]Ro15-1788 from human recombinant GABA-Aalpha1 receptor plus beta3gamma2 | Bioorg Med Chem Lett 16: 1582-5 (2006) Article DOI: 10.1016/j.bmcl.2005.12.027 BindingDB Entry DOI: 10.7270/Q25B022B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GABA receptor alpha-3/beta-3/gamma-2 subunit (Homo sapiens (Human)) | BDBM50179853 (5'-(7-ethyl-8-oxo-7,8-dihydroimidazo[1,2-a]pyrazin...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck, Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]Ro15-1788 from human recombinant GABA-Aalpha3 receptor plus beta3gamma2 | Bioorg Med Chem Lett 16: 1582-5 (2006) Article DOI: 10.1016/j.bmcl.2005.12.027 BindingDB Entry DOI: 10.7270/Q25B022B | |||||||||||
More data for this Ligand-Target Pair |