BDBM50180374 3-(2-methoxypyridin-4-yl)-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine::CHEMBL383467
SMILES: COc1cc(ccn1)-c1cnc2nc(ccn12)C(F)(F)F
InChI Key: InChIKey=HAHDKXDDOBLEEH-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GABA receptor alpha-1/beta-3/gamma-2 subunit (Homo sapiens (Human)) | BDBM50180374![]() (3-(2-methoxypyridin-4-yl)-7-(trifluoromethyl)imida...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]Ro 15-1788 from recombinant human GABA-Aalpha1 receptor plus beta3gamma2 expressed in L(tk-) cells | Bioorg Med Chem Lett 16: 1175-9 (2006) Article DOI: 10.1016/j.bmcl.2005.11.112 BindingDB Entry DOI: 10.7270/Q2FN15SZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GABA receptor alpha-3/beta-3/gamma-2 subunit (Homo sapiens (Human)) | BDBM50180374![]() (3-(2-methoxypyridin-4-yl)-7-(trifluoromethyl)imida...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | >33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Displacement of [3H]Ro 15-1788 from recombinant human GABA-Aalpha3 receptor plus beta3gamma2 expressed in L(tk-) cells | Bioorg Med Chem Lett 16: 1175-9 (2006) Article DOI: 10.1016/j.bmcl.2005.11.112 BindingDB Entry DOI: 10.7270/Q2FN15SZ | |||||||||||
More data for this Ligand-Target Pair |