null

SMILES: CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O

InChI Key: InChIKey=HLUQDWRHBPWVNT-LVHVEONVSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 71 hits for monomerid = 50180786   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E111A				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41.1	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N305D				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10.3	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR W280F				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q208E				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D293N				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	65.1	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR F309Q				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR K191E				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR T190K				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	192	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y290Q				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N27E				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.90	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR M24A				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H182A				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S186D				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	951	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y290L				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D293K				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S118A				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y284F				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10.5	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E111K				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D293E				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E295A				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E295Q				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S168A				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR F313L				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L117A				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S124A				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	37.7	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR F309L				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.10	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from human wild type GnRHR				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	48.8	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y290F				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D293A				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N315D				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	186	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y284L				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18.2	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L300A				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S168I				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N27A				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR N315A				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR E295K				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H182E				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR A50T				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50.6	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H306A				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR K115Q				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR S186K				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q189K				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	42.2	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR D302A				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10.1	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q208D				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16.7	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Q189E				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	267	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR K121A				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	316	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR Y283F				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	66.2	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR H306K				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR F272L				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50180786 (CHEMBL436874 | pGlu-His-Trp-Ser-His-D-Tyr-Leu-Arg-...) Show SMILES CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O |wU:54.58,30.43,12.21,4.4,wD:44.54,24.27,64.67,78.83,(20.78,-2.99,;20.78,-4.53,;22.11,-5.3,;19.45,-5.3,;19.45,-6.85,;18.11,-7.62,;16.78,-6.85,;16.78,-5.31,;15.44,-7.63,;14.11,-6.85,;12.78,-7.62,;12.78,-9.17,;11.45,-6.86,;11.45,-5.31,;12.78,-4.54,;14.1,-5.31,;15.44,-4.54,;15.43,-3,;16.77,-2.23,;14.1,-2.23,;12.77,-3,;10.11,-7.63,;8.77,-6.86,;8.77,-5.31,;7.44,-7.63,;7.44,-9.17,;8.77,-9.94,;6.12,-6.86,;4.77,-7.63,;4.77,-9.17,;3.44,-6.86,;3.44,-5.32,;4.77,-4.55,;6.17,-5.17,;7.2,-4.03,;6.43,-2.7,;6.91,-1.24,;5.87,-.1,;4.37,-.41,;3.9,-1.88,;4.94,-3.02,;2.11,-7.64,;.77,-6.87,;.77,-5.32,;-.56,-7.64,;-.56,-9.18,;.78,-9.95,;2.18,-9.32,;3.22,-10.46,;2.44,-11.79,;.95,-11.47,;-1.89,-6.87,;-3.23,-7.64,;-3.23,-9.18,;-4.57,-6.87,;-5.9,-7.64,;-4.57,-5.33,;-3.24,-4.57,;-3.24,-3.02,;-4.57,-2.25,;-1.89,-2.25,;20.78,-7.61,;20.78,-9.15,;22.12,-6.84,;23.44,-7.61,;23.44,-9.14,;22.12,-9.92,;22.12,-11.46,;20.79,-12.23,;19.46,-11.46,;19.46,-9.92,;18.12,-12.23,;24.78,-6.84,;24.78,-5.3,;26.12,-7.6,;26.43,-9.25,;28.08,-9.48,;28.81,-7.98,;27.53,-7.1,;27.73,-5.57,;26.5,-4.64,;29.15,-4.98,;30.38,-5.91,;31.8,-5.32,;33.03,-6.25,;32,-3.79,)| Show InChI InChI=1S/C55H76N16O15/c1-29(2)19-38(49(81)66-37(9-5-17-60-55(57)58)54(86)71-18-6-10-43(71)53(85)63-26-46(77)78)65-44(74)25-62-48(80)39(20-30-11-13-33(73)14-12-30)68-52(84)42(27-72)70-50(82)40(21-31-23-61-36-8-4-3-7-34(31)36)69-51(83)41(22-32-24-59-28-64-32)67-47(79)35(56)15-16-45(75)76/h3-4,7-8,11-14,23-24,28-29,35,37-43,61,72-73H,5-6,9-10,15-22,25-27,56H2,1-2H3,(H,59,64)(H,62,80)(H,63,85)(H,65,74)(H,66,81)(H,67,79)(H,68,84)(H,69,83)(H,70,82)(H,75,76)(H,77,78)(H4,57,58,60)/t35-,37-,38-,39-,40-,41-,42-,43-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-His5, D-Tyr6]GnRH from mutant GnRHR, GnRHR L112F				J Med Chem 49: 637-47 (2006) Article DOI: 10.1021/jm0506928 BindingDB Entry DOI: 10.7270/Q24749GS
					More data for this Ligand-Target Pair