BDBM50181821 CHEMBL202071::O-(p-trifluoromethyl)benzyl-tyramine
SMILES: NCCc1ccc(OCc2ccc(cc2)C(F)(F)F)cc1
InChI Key: InChIKey=WDYBTWXDYUCILG-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Amine oxidase [flavin-containing] B (Homo sapiens (Human)) | BDBM50181821 (CHEMBL202071 | O-(p-trifluoromethyl)benzyl-tyramin...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yonsei University Curated by ChEMBL | Assay Description Competitive inhibition of recombinant human MAO-B using varying level of benzylamine substrate preincubated for 15 mins followed by substrate additio... | Bioorg Med Chem 26: 232-244 (2018) Article DOI: 10.1016/j.bmc.2017.11.036 BindingDB Entry DOI: 10.7270/Q2959M4S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trace amine-associated receptor 1 (TAAR1) (Rattus norvegicus (Rat)) | BDBM50181821 (CHEMBL202071 | O-(p-trifluoromethyl)benzyl-tyramin...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a |
University of California at San Francisco Curated by ChEMBL | Assay Description Activity at rat TAAR1 by measuring cAMP accumulation in HEK293 cells | J Med Chem 49: 1101-12 (2006) Article DOI: 10.1021/jm0505718 BindingDB Entry DOI: 10.7270/Q2416WNR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase (flavin-containing) A (Homo sapiens (Human)) | BDBM50181821 (CHEMBL202071 | O-(p-trifluoromethyl)benzyl-tyramin...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Yonsei University Curated by ChEMBL | Assay Description Inhibition of recombinant human MAO-A using p-tyramine as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by... | Bioorg Med Chem 26: 232-244 (2018) Article DOI: 10.1016/j.bmc.2017.11.036 BindingDB Entry DOI: 10.7270/Q2959M4S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trace amine-associated receptor 1 (TAAR1) (Mus musculus (Mouse)) | BDBM50181821 (CHEMBL202071 | O-(p-trifluoromethyl)benzyl-tyramin...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 20.2 | n/a | n/a | n/a | n/a |
University of California at San Francisco Curated by ChEMBL | Assay Description Activity at mouse TAAR1 by measuring cAMP accumulation in HEK293 cells | J Med Chem 49: 1101-12 (2006) Article DOI: 10.1021/jm0505718 BindingDB Entry DOI: 10.7270/Q2416WNR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase [flavin-containing] B (Homo sapiens (Human)) | BDBM50181821 (CHEMBL202071 | O-(p-trifluoromethyl)benzyl-tyramin...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Yonsei University Curated by ChEMBL | Assay Description Inhibition of recombinant human MAO-B using benzylamine as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins b... | Bioorg Med Chem 26: 232-244 (2018) Article DOI: 10.1016/j.bmc.2017.11.036 BindingDB Entry DOI: 10.7270/Q2959M4S | |||||||||||
More data for this Ligand-Target Pair |