BDBM50182559 1-(3,4-dihydroxyphenyl)-2-pyrrolidin-1-yl-pentan-1-one::CHEMBL202846
SMILES: CCCC(N1CCCC1)C(=O)c1ccc(O)c(O)c1
InChI Key: InChIKey=KKTUFJIEHNEGDF-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50182559![]() (1-(3,4-dihydroxyphenyl)-2-pyrrolidin-1-yl-pentan-1...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 84 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc. Curated by ChEMBL | Assay Description Displacement of [125I]RTI-55 from human DAT expressed in HEK293 cells | J Med Chem 49: 1420-32 (2006) Article DOI: 10.1021/jm050797a BindingDB Entry DOI: 10.7270/Q2KK9CKB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50182559![]() (1-(3,4-dihydroxyphenyl)-2-pyrrolidin-1-yl-pentan-1...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 219 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc. Curated by ChEMBL | Assay Description Displacement of [125I]RTI-55 from human NET expressed in HEK293 cells | J Med Chem 49: 1420-32 (2006) Article DOI: 10.1021/jm050797a BindingDB Entry DOI: 10.7270/Q2KK9CKB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50182559![]() (1-(3,4-dihydroxyphenyl)-2-pyrrolidin-1-yl-pentan-1...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc. Curated by ChEMBL | Assay Description Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cells | J Med Chem 49: 1420-32 (2006) Article DOI: 10.1021/jm050797a BindingDB Entry DOI: 10.7270/Q2KK9CKB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50182559![]() (1-(3,4-dihydroxyphenyl)-2-pyrrolidin-1-yl-pentan-1...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc. Curated by ChEMBL | Assay Description Inhibition of [3H] norepinephrine uptake into human NET expressed in HEK293 cells | J Med Chem 49: 1420-32 (2006) Article DOI: 10.1021/jm050797a BindingDB Entry DOI: 10.7270/Q2KK9CKB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50182559![]() (1-(3,4-dihydroxyphenyl)-2-pyrrolidin-1-yl-pentan-1...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc. Curated by ChEMBL | Assay Description Inhibition of [3H] dopamine uptake into human DAT expressed in HEK293 cells | J Med Chem 49: 1420-32 (2006) Article DOI: 10.1021/jm050797a BindingDB Entry DOI: 10.7270/Q2KK9CKB | |||||||||||
More data for this Ligand-Target Pair |