Found 12 hits for monomerid = 50182578 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50182578
(1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one |...)Show InChI InChI=1S/C15H20BrNO/c1-2-5-14(17-10-3-4-11-17)15(18)12-6-8-13(16)9-7-12/h6-9,14H,2-5,10-11H2,1H3 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc.
Curated by ChEMBL
| Assay Description Displacement of [125I]RTI-55 from human DAT expressed in HEK293 cells |
J Med Chem 49: 1420-32 (2006)
Article DOI: 10.1021/jm050797a BindingDB Entry DOI: 10.7270/Q2KK9CKB |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50182578
(1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one |...)Show InChI InChI=1S/C15H20BrNO/c1-2-5-14(17-10-3-4-11-17)15(18)12-6-8-13(16)9-7-12/h6-9,14H,2-5,10-11H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 386 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc.
Curated by ChEMBL
| Assay Description Displacement of [125I]RTI-55 from human NET expressed in HEK293 cells |
J Med Chem 49: 1420-32 (2006)
Article DOI: 10.1021/jm050797a BindingDB Entry DOI: 10.7270/Q2KK9CKB |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50182578
(1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one |...)Show InChI InChI=1S/C15H20BrNO/c1-2-5-14(17-10-3-4-11-17)15(18)12-6-8-13(16)9-7-12/h6-9,14H,2-5,10-11H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 830 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc.
Curated by ChEMBL
| Assay Description Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cells |
J Med Chem 49: 1420-32 (2006)
Article DOI: 10.1021/jm050797a BindingDB Entry DOI: 10.7270/Q2KK9CKB |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50182578
(1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one |...)Show InChI InChI=1S/C15H20BrNO/c1-2-5-14(17-10-3-4-11-17)15(18)12-6-8-13(16)9-7-12/h6-9,14H,2-5,10-11H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H] norepinephrine uptake into human NET expressed in HEK293 cells |
J Med Chem 49: 1420-32 (2006)
Article DOI: 10.1021/jm050797a BindingDB Entry DOI: 10.7270/Q2KK9CKB |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50182578
(1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one |...)Show InChI InChI=1S/C15H20BrNO/c1-2-5-14(17-10-3-4-11-17)15(18)12-6-8-13(16)9-7-12/h6-9,14H,2-5,10-11H2,1H3 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 39.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H] dopamine uptake into human DAT expressed in HEK293 cells |
J Med Chem 49: 1420-32 (2006)
Article DOI: 10.1021/jm050797a BindingDB Entry DOI: 10.7270/Q2KK9CKB |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1B
(Homo sapiens (Human)) | BDBM50182578
(1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one |...)Show InChI InChI=1S/C15H20BrNO/c1-2-5-14(17-10-3-4-11-17)15(18)12-6-8-13(16)9-7-12/h6-9,14H,2-5,10-11H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc.
Curated by ChEMBL
| Assay Description Inhibitory activity against 5HT1B |
J Med Chem 49: 1420-32 (2006)
Article DOI: 10.1021/jm050797a BindingDB Entry DOI: 10.7270/Q2KK9CKB |
More data for this Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50182578
(1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one |...)Show InChI InChI=1S/C15H20BrNO/c1-2-5-14(17-10-3-4-11-17)15(18)12-6-8-13(16)9-7-12/h6-9,14H,2-5,10-11H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc.
Curated by ChEMBL
| Assay Description Inhibitory activity against dopamine D3 |
J Med Chem 49: 1420-32 (2006)
Article DOI: 10.1021/jm050797a BindingDB Entry DOI: 10.7270/Q2KK9CKB |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50182578
(1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one |...)Show InChI InChI=1S/C15H20BrNO/c1-2-5-14(17-10-3-4-11-17)15(18)12-6-8-13(16)9-7-12/h6-9,14H,2-5,10-11H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc.
Curated by ChEMBL
| Assay Description Inhibitory activity against 5HT1C |
J Med Chem 49: 1420-32 (2006)
Article DOI: 10.1021/jm050797a BindingDB Entry DOI: 10.7270/Q2KK9CKB |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50182578
(1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one |...)Show InChI InChI=1S/C15H20BrNO/c1-2-5-14(17-10-3-4-11-17)15(18)12-6-8-13(16)9-7-12/h6-9,14H,2-5,10-11H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc.
Curated by ChEMBL
| Assay Description Inhibitory activity against dopamine D2 |
J Med Chem 49: 1420-32 (2006)
Article DOI: 10.1021/jm050797a BindingDB Entry DOI: 10.7270/Q2KK9CKB |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50182578
(1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one |...)Show InChI InChI=1S/C15H20BrNO/c1-2-5-14(17-10-3-4-11-17)15(18)12-6-8-13(16)9-7-12/h6-9,14H,2-5,10-11H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc.
Curated by ChEMBL
| Assay Description Inhibition of [3H] serotonin uptake into human SERT expressed in HEK293 cells |
J Med Chem 49: 1420-32 (2006)
Article DOI: 10.1021/jm050797a BindingDB Entry DOI: 10.7270/Q2KK9CKB |
More data for this Ligand-Target Pair | |
D(1A) dopamine receptor
(Homo sapiens (Human)) | BDBM50182578
(1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one |...)Show InChI InChI=1S/C15H20BrNO/c1-2-5-14(17-10-3-4-11-17)15(18)12-6-8-13(16)9-7-12/h6-9,14H,2-5,10-11H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc.
Curated by ChEMBL
| Assay Description Inhibitory activity against dopamine D1 |
J Med Chem 49: 1420-32 (2006)
Article DOI: 10.1021/jm050797a BindingDB Entry DOI: 10.7270/Q2KK9CKB |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50182578
(1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one |...)Show InChI InChI=1S/C15H20BrNO/c1-2-5-14(17-10-3-4-11-17)15(18)12-6-8-13(16)9-7-12/h6-9,14H,2-5,10-11H2,1H3 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Organix Inc.
Curated by ChEMBL
| Assay Description Inhibitory activity against 5HT1A |
J Med Chem 49: 1420-32 (2006)
Article DOI: 10.1021/jm050797a BindingDB Entry DOI: 10.7270/Q2KK9CKB |
More data for this Ligand-Target Pair | |