BDBM50184796 1-((5-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-phenylpiperazine::CHEMBL377200

SMILES: Cc1c(CN2CCN(CC2)c2ccccc2)cnn1-c1ccccc1

InChI Key: InChIKey=VFZKZZYPGOBKJY-UHFFFAOYSA-N

Data: 5 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50184796   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50184796 (1-((5-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-ph...) Show SMILES Cc1c(CN2CCN(CC2)c2ccccc2)cnn1-c1ccccc1 Show InChI InChI=1S/C21H24N4/c1-18-19(16-22-25(18)21-10-6-3-7-11-21)17-23-12-14-24(15-13-23)20-8-4-2-5-9-20/h2-11,16H,12-15,17H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from human cloned dopamine D4 receptor expressed in CHO cells				Bioorg Med Chem Lett 16: 2955-9 (2006) Article DOI: 10.1016/j.bmcl.2006.02.075 BindingDB Entry DOI: 10.7270/Q21N80QX
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50184796 (1-((5-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-ph...) Show SMILES Cc1c(CN2CCN(CC2)c2ccccc2)cnn1-c1ccccc1 Show InChI InChI=1S/C21H24N4/c1-18-19(16-22-25(18)21-10-6-3-7-11-21)17-23-12-14-24(15-13-23)20-8-4-2-5-9-20/h2-11,16H,12-15,17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	250	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from human cloned dopamine D2(short) receptor expressed in CHO cells				Bioorg Med Chem Lett 16: 2955-9 (2006) Article DOI: 10.1016/j.bmcl.2006.02.075 BindingDB Entry DOI: 10.7270/Q21N80QX
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50184796 (1-((5-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-ph...) Show SMILES Cc1c(CN2CCN(CC2)c2ccccc2)cnn1-c1ccccc1 Show InChI InChI=1S/C21H24N4/c1-18-19(16-22-25(18)21-10-6-3-7-11-21)17-23-12-14-24(15-13-23)20-8-4-2-5-9-20/h2-11,16H,12-15,17H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	320	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from human cloned dopamine D3 receptor expressed in CHO cells				Bioorg Med Chem Lett 16: 2955-9 (2006) Article DOI: 10.1016/j.bmcl.2006.02.075 BindingDB Entry DOI: 10.7270/Q21N80QX
					More data for this Ligand-Target Pair
Dopamine D1 receptor (Sus scrofa)	BDBM50184796 (1-((5-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-ph...) Show SMILES Cc1c(CN2CCN(CC2)c2ccccc2)cnn1-c1ccccc1 Show InChI InChI=1S/C21H24N4/c1-18-19(16-22-25(18)21-10-6-3-7-11-21)17-23-12-14-24(15-13-23)20-8-4-2-5-9-20/h2-11,16H,12-15,17H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	560	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membrane				Bioorg Med Chem Lett 16: 2955-9 (2006) Article DOI: 10.1016/j.bmcl.2006.02.075 BindingDB Entry DOI: 10.7270/Q21N80QX
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50184796 (1-((5-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-ph...) Show SMILES Cc1c(CN2CCN(CC2)c2ccccc2)cnn1-c1ccccc1 Show InChI InChI=1S/C21H24N4/c1-18-19(16-22-25(18)21-10-6-3-7-11-21)17-23-12-14-24(15-13-23)20-8-4-2-5-9-20/h2-11,16H,12-15,17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	630	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Friedrich-Alexander University Curated by ChEMBL					Assay Description Displacement of [3H]spiperone from human cloned dopamine D2(long) receptor expressed in CHO cells				Bioorg Med Chem Lett 16: 2955-9 (2006) Article DOI: 10.1016/j.bmcl.2006.02.075 BindingDB Entry DOI: 10.7270/Q21N80QX
					More data for this Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo) (Homo sapiens (Human))	BDBM50184796 (1-((5-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-ph...) Show SMILES Cc1c(CN2CCN(CC2)c2ccccc2)cnn1-c1ccccc1 Show InChI InChI=1S/C21H24N4/c1-18-19(16-22-25(18)21-10-6-3-7-11-21)17-23-12-14-24(15-13-23)20-8-4-2-5-9-20/h2-11,16H,12-15,17H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assay				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
					More data for this Ligand-Target Pair
G-protein- coupled-like receptor Smoothened (Smo) (Homo sapiens (Human))	BDBM50184796 (1-((5-methyl-1-phenyl-1H-pyrazol-4-yl)methyl)-4-ph...) Show SMILES Cc1c(CN2CCN(CC2)c2ccccc2)cnn1-c1ccccc1 Show InChI InChI=1S/C21H24N4/c1-18-19(16-22-25(18)21-10-6-3-7-11-21)17-23-12-14-24(15-13-23)20-8-4-2-5-9-20/h2-11,16H,12-15,17H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	96	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of Smoothened transfected in HEK293 cells by binding assay				Bioorg Med Chem Lett 20: 4932-5 (2010) Article DOI: 10.1016/j.bmcl.2010.06.033 BindingDB Entry DOI: 10.7270/Q22V2G9F
					More data for this Ligand-Target Pair