BDBM50186583 CHEMBL380065::cis-1-(3-allyl-1-(2,5-difluorophenyl)cyclohexylsulfonyl)-4-chlorobenzene

SMILES: Fc1ccc(F)c(c1)[C@@]1(CCC[C@@H](CC=C)C1)S(=O)(=O)c1ccc(Cl)cc1

InChI Key: InChIKey=QYZZHKZREHQWLD-VFNWGFHPSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50186583   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gamma-Secretase Subunit APH-1A/Gamma-Secretase Subunit PEN-2/Gamma-Secretase Subunit Presenilin-1/Gamma-secretase subunit APH-1B/Nicastrin /Presenilin 2 (Homo sapiens (Human))	BDBM50186583 (CHEMBL380065 | cis-1-(3-allyl-1-(2,5-difluoropheny...) Show SMILES Fc1ccc(F)c(c1)[C@@]1(CCC[C@@H](CC=C)C1)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H21ClF2O2S/c1-2-4-15-5-3-12-21(14-15,19-13-17(23)8-11-20(19)24)27(25,26)18-9-6-16(22)7-10-18/h2,6-11,13,15H,1,3-5,12,14H2/t15-,21+/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description Inhibition of gamma secretase expressed in SH-SY5Y cells				Bioorg Med Chem Lett 16: 3839-42 (2006) Article DOI: 10.1016/j.bmcl.2006.04.019 BindingDB Entry DOI: 10.7270/Q2BP02DT
					More data for this Ligand-Target Pair