BDBM50188059 1-(1,2-diphenylethyl)piperazine::CHEMBL214237
SMILES: C(C(N1CCNCC1)c1ccccc1)c1ccccc1
InChI Key: InChIKey=NIBIYLDNVMUKNB-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50188059 (1-(1,2-diphenylethyl)piperazine | CHEMBL214237) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of DA transporter expressed in HEK293 cells | Bioorg Med Chem Lett 16: 4345-8 (2006) Article DOI: 10.1016/j.bmcl.2006.05.051 BindingDB Entry DOI: 10.7270/Q2H99608 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50188059 (1-(1,2-diphenylethyl)piperazine | CHEMBL214237) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of [3H]5-HT uptake at 5HT transporter expressed in HEK293 cells | Bioorg Med Chem Lett 16: 4345-8 (2006) Article DOI: 10.1016/j.bmcl.2006.05.051 BindingDB Entry DOI: 10.7270/Q2H99608 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50188059 (1-(1,2-diphenylethyl)piperazine | CHEMBL214237) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of [3H]NA uptake at NA transporter expressed in HEK293 cells | Bioorg Med Chem Lett 16: 4345-8 (2006) Article DOI: 10.1016/j.bmcl.2006.05.051 BindingDB Entry DOI: 10.7270/Q2H99608 | |||||||||||
More data for this Ligand-Target Pair |