BDBM50192366 5-ethyl-9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione::CHEMBL384369

SMILES: CCc1c(c2C(=O)NC(=O)c2c2c1[nH]c1ccc(O)cc21)-c1ccccc1

InChI Key: InChIKey=MNXSFHOIYMHBJG-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50192366   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50192366 (5-ethyl-9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-...) Show SMILES CCc1c(c2C(=O)NC(=O)c2c2c1[nH]c1ccc(O)cc21)-c1ccccc1 Show InChI InChI=1S/C22H16N2O3/c1-2-13-16(11-6-4-3-5-7-11)18-19(22(27)24-21(18)26)17-14-10-12(25)8-9-15(14)23-20(13)17/h3-10,23,25H,2H2,1H3,(H,24,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition at human Chk1 in presence of 4 uM ATP				J Med Chem 49: 4896-911 (2006) Article DOI: 10.1021/jm0512591 BindingDB Entry DOI: 10.7270/Q23778BD
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50192366 (5-ethyl-9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-...) Show SMILES CCc1c(c2C(=O)NC(=O)c2c2c1[nH]c1ccc(O)cc21)-c1ccccc1 Show InChI InChI=1S/C22H16N2O3/c1-2-13-16(11-6-4-3-5-7-11)18-19(22(27)24-21(18)26)17-14-10-12(25)8-9-15(14)23-20(13)17/h3-10,23,25H,2H2,1H3,(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.62E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chulalongkorn University Curated by ChEMBL					Assay Description Inhibition of human Wee1				Eur J Med Chem 44: 1383-95 (2009) Article DOI: 10.1016/j.ejmech.2008.09.027 BindingDB Entry DOI: 10.7270/Q2X34XB6
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase WEE1 (Homo sapiens (Human))	BDBM50192366 (5-ethyl-9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-...) Show SMILES CCc1c(c2C(=O)NC(=O)c2c2c1[nH]c1ccc(O)cc21)-c1ccccc1 Show InChI InChI=1S/C22H16N2O3/c1-2-13-16(11-6-4-3-5-7-11)18-19(22(27)24-21(18)26)17-14-10-12(25)8-9-15(14)23-20(13)17/h3-10,23,25H,2H2,1H3,(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of human Wee1 in presence of 9.5 uM ATP				J Med Chem 49: 4896-911 (2006) Article DOI: 10.1021/jm0512591 BindingDB Entry DOI: 10.7270/Q23778BD
					More data for this Ligand-Target Pair