BDBM50192771 CHEMBL3898371
SMILES: [H][C@]1(C)COC(=O)Nc2ccc(c(CN(C)C(=O)[C@]([H])(Nc3ccc4c(c3)c(F)c[nH]c4=N)c3ccc1c(C)c3)c2)C1(CC1)C(O)=O
InChI Key: InChIKey=RFKOYFYQZZFWKX-ADXZGYQBSA-N
Data: 5 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Coagulation factor III/Factor VIIa (fVIIa) (Homo sapiens (Human)) | BDBM50192771 (CHEMBL3898371) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 0.550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development Curated by ChEMBL | Assay Description Inhibition of recombinant human TF-factor 7a using factor 10 as substrate at 37 degC | Bioorg Med Chem Lett 26: 5051-5057 (2016) Article DOI: 10.1016/j.bmcl.2016.08.088 BindingDB Entry DOI: 10.7270/Q24X59Q6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vitamin K-dependent protein C (Homo sapiens (Human)) | BDBM50192771 (CHEMBL3898371) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development Curated by ChEMBL | Assay Description Inhibition of activated protein C (unknown origin) at 37 degC by chromogenic substrate assay | Bioorg Med Chem Lett 26: 5051-5057 (2016) Article DOI: 10.1016/j.bmcl.2016.08.088 BindingDB Entry DOI: 10.7270/Q24X59Q6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kallikrein 1 (Homo sapiens (Human)) | BDBM50192771 (CHEMBL3898371) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development Curated by ChEMBL | Assay Description Inhibition of human kallikrein1 at 37 degC by chromogenic substrate assay | Bioorg Med Chem Lett 26: 5051-5057 (2016) Article DOI: 10.1016/j.bmcl.2016.08.088 BindingDB Entry DOI: 10.7270/Q24X59Q6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM50192771 (CHEMBL3898371) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 6.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development Curated by ChEMBL | Assay Description Inhibition of factor 10a (unknown origin) at 25 degC by chromogenic substrate assay | Bioorg Med Chem Lett 26: 5051-5057 (2016) Article DOI: 10.1016/j.bmcl.2016.08.088 BindingDB Entry DOI: 10.7270/Q24X59Q6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50192771 (CHEMBL3898371) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | >1.33E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development Curated by ChEMBL | Assay Description Inhibition of thrombin (unknown origin) at 25 degC by chromogenic substrate assay | Bioorg Med Chem Lett 26: 5051-5057 (2016) Article DOI: 10.1016/j.bmcl.2016.08.088 BindingDB Entry DOI: 10.7270/Q24X59Q6 | |||||||||||
More data for this Ligand-Target Pair |