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BDBM50192908 CHEMBL3895629::US9775844, Compound 59

SMILES: C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3nccs3)c2c(=O)n1-c1ccccc1

InChI Key: InChIKey=LHUTWLRZEUBNQJ-LGWFVXIRNA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50192908   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50192908
PNG
(CHEMBL3895629 | US9775844, Compound 59)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3nccs3)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1/C29H21N7O2S/c1-18(33-28(37)25-26(30)34-35-15-6-13-32-27(25)35)22-17-20-8-5-7-19(11-12-23-31-14-16-39-23)24(20)29(38)36(22)21-9-3-2-4-10-21/h2-10,13-18H,1H3,(H2,30,34)(H,33,37)/t18-/s2
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n/an/a 360n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...


ACS Med Chem Lett 7: 862-7 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00238
BindingDB Entry DOI: 10.7270/Q2N018HX
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), delta


(Homo sapiens (Human))
BDBM50192908
PNG
(CHEMBL3895629 | US9775844, Compound 59)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3nccs3)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1/C29H21N7O2S/c1-18(33-28(37)25-26(30)34-35-15-6-13-32-27(25)35)22-17-20-8-5-7-19(11-12-23-31-14-16-39-23)24(20)29(38)36(22)21-9-3-2-4-10-21/h2-10,13-18H,1H3,(H2,30,34)(H,33,37)/t18-/s2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full length N-terminal GST-tagged PI3K p110delta/p85alpha coexpressed in baculovirus infected Sf9 insect cells using ...


ACS Med Chem Lett 7: 862-7 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00238
BindingDB Entry DOI: 10.7270/Q2N018HX
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50192908
PNG
(CHEMBL3895629 | US9775844, Compound 59)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3nccs3)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1/C29H21N7O2S/c1-18(33-28(37)25-26(30)34-35-15-6-13-32-27(25)35)22-17-20-8-5-7-19(11-12-23-31-14-16-39-23)24(20)29(38)36(22)21-9-3-2-4-10-21/h2-10,13-18H,1H3,(H2,30,34)(H,33,37)/t18-/s2
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n/an/a 3.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent




US Patent US9775844 (2017)


BindingDB Entry DOI: 10.7270/Q2GQ70WH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50192908
PNG
(CHEMBL3895629 | US9775844, Compound 59)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3nccs3)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1/C29H21N7O2S/c1-18(33-28(37)25-26(30)34-35-15-6-13-32-27(25)35)22-17-20-8-5-7-19(11-12-23-31-14-16-39-23)24(20)29(38)36(22)21-9-3-2-4-10-21/h2-10,13-18H,1H3,(H2,30,34)(H,33,37)/t18-/s2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent




US Patent US9775844 (2017)


BindingDB Entry DOI: 10.7270/Q2GQ70WH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50192908
PNG
(CHEMBL3895629 | US9775844, Compound 59)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3nccs3)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1/C29H21N7O2S/c1-18(33-28(37)25-26(30)34-35-15-6-13-32-27(25)35)22-17-20-8-5-7-19(11-12-23-31-14-16-39-23)24(20)29(38)36(22)21-9-3-2-4-10-21/h2-10,13-18H,1H3,(H2,30,34)(H,33,37)/t18-/s2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent




US Patent US9775844 (2017)


BindingDB Entry DOI: 10.7270/Q2GQ70WH
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50192908
PNG
(CHEMBL3895629 | US9775844, Compound 59)
Show SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3nccs3)c2c(=O)n1-c1ccccc1 |r|
Show InChI InChI=1/C29H21N7O2S/c1-18(33-28(37)25-26(30)34-35-15-6-13-32-27(25)35)22-17-20-8-5-7-19(11-12-23-31-14-16-39-23)24(20)29(38)36(22)21-9-3-2-4-10-21/h2-10,13-18H,1H3,(H2,30,34)(H,33,37)/t18-/s2
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PC sid
UniChem
US Patent
n/an/a 2.00E+3n/an/an/an/an/an/a



Infinity Pharmaceuticals, Inc.

US Patent




US Patent US9775844 (2017)


BindingDB Entry DOI: 10.7270/Q2GQ70WH
More data for this
Ligand-Target Pair