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SMILES: Cc1cc(C)c(CNC(=O)c2ccccc2C)c(=O)[nH]1

InChI Key: InChIKey=ZQAHDUVRAUNQMF-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50193716   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))		BDBM50193716
PNG
(CHEMBL3984466)
Show SMILES Cc1cc(C)c(CNC(=O)c2ccccc2C)c(=O)[nH]1
Show InChI InChI=1S/C16H18N2O2/c1-10-6-4-5-7-13(10)15(19)17-9-14-11(2)8-12(3)18-16(14)20/h4-8H,9H2,1-3H3,(H,17,19)(H,18,20)
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Article
PubMed
n/an/a>2.00E+5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild-type EZH2 (unknown origin) expressed in baculovirus infected SF9 cells co-expressing SUZ12/EED/RbAp48 complex using HeLa cells der...

J Med Chem 59: 8306-25 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00515
BindingDB Entry DOI: 10.7270/Q2J1053B
More data for this
Ligand-Target Pair