BDBM50194735 CHEMBL215961::diphenyl 1-[(N-p-cyanobenzenesulfonyl-D-seryl)-L-alanyl]-amino-2-(4-guanidinophenyl)ethane-phosphonate

SMILES: [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]S(=O)(=O)c1ccc(cc1)C#N)-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1

InChI Key: InChIKey=QDCFZMDANJYLAS-NJIWFKEJSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50194735   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50194735 (CHEMBL215961 | diphenyl 1-[(N-p-cyanobenzenesulfon...) Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]S(=O)(=O)c1ccc(cc1)C#N)-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C34H36N7O8PS/c1-23(38-33(44)30(22-42)41-51(46,47)29-18-14-25(21-35)15-19-29)32(43)40-31(20-24-12-16-26(17-13-24)39-34(36)37)50(45,48-27-8-4-2-5-9-27)49-28-10-6-3-7-11-28/h2-19,23,30-31,41-42H,20,22H2,1H3,(H,38,44)(H,40,43)(H4,36,37,39)/t23-,30+,31?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50194735 (CHEMBL215961 | diphenyl 1-[(N-p-cyanobenzenesulfon...) Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]S(=O)(=O)c1ccc(cc1)C#N)-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C34H36N7O8PS/c1-23(38-33(44)30(22-42)41-51(46,47)29-18-14-25(21-35)15-19-29)32(43)40-31(20-24-12-16-26(17-13-24)39-34(36)37)50(45,48-27-8-4-2-5-9-27)49-28-10-6-3-7-11-28/h2-19,23,30-31,41-42H,20,22H2,1H3,(H,38,44)(H,40,43)(H4,36,37,39)/t23-,30+,31?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human thrombin				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50194735 (CHEMBL215961 | diphenyl 1-[(N-p-cyanobenzenesulfon...) Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]S(=O)(=O)c1ccc(cc1)C#N)-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C34H36N7O8PS/c1-23(38-33(44)30(22-42)41-51(46,47)29-18-14-25(21-35)15-19-29)32(43)40-31(20-24-12-16-26(17-13-24)39-34(36)37)50(45,48-27-8-4-2-5-9-27)49-28-10-6-3-7-11-28/h2-19,23,30-31,41-42H,20,22H2,1H3,(H,38,44)(H,40,43)(H4,36,37,39)/t23-,30+,31?/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human plasmin				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM50194735 (CHEMBL215961 | diphenyl 1-[(N-p-cyanobenzenesulfon...) Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]S(=O)(=O)c1ccc(cc1)C#N)-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C34H36N7O8PS/c1-23(38-33(44)30(22-42)41-51(46,47)29-18-14-25(21-35)15-19-29)32(43)40-31(20-24-12-16-26(17-13-24)39-34(36)37)50(45,48-27-8-4-2-5-9-27)49-28-10-6-3-7-11-28/h2-19,23,30-31,41-42H,20,22H2,1H3,(H,38,44)(H,40,43)(H4,36,37,39)/t23-,30+,31?/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of recombinant tPA				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
					More data for this Ligand-Target Pair