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BDBM50194984 4-(3-chloro-4-fluoro-phenylamino)-6-[(1-oxy-pyridin-2-ylmethyl)-amino]-quinoline-3-carbonitrile::CHEMBL222666

SMILES: [O-][n+]1ccccc1CNc1ccc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2c1

InChI Key: InChIKey=HNDXAKQDIXACOH-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50194984   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (Human))
BDBM50194984
PNG
(4-(3-chloro-4-fluoro-phenylamino)-6-[(1-oxy-pyridi...)
Show SMILES [O-][n+]1ccccc1CNc1ccc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2c1
Show InChI InChI=1S/C22H15ClFN5O/c23-19-10-16(4-6-20(19)24)28-22-14(11-25)12-27-21-7-5-15(9-18(21)22)26-13-17-3-1-2-8-29(17)30/h1-10,12,26H,13H2,(H,27,28)
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 110n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Tpl2 kinase by ELISA


Bioorg Med Chem Lett 16: 6067-72 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.102
BindingDB Entry DOI: 10.7270/Q2W958TR
More data for this
Ligand-Target Pair