BDBM50194996 4-(3-chloro-4-fluorophenylthio)-6-(2-morpholinoethylamino)quinoline-3-carbonitrile::CHEMBL374785

SMILES: Fc1ccc(Sc2c(cnc3ccc(NCCN4CCOCC4)cc23)C#N)cc1Cl

InChI Key: InChIKey=XANONFHPKVXODH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50194996   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50194996 (4-(3-chloro-4-fluorophenylthio)-6-(2-morpholinoeth...) Show SMILES Fc1ccc(Sc2c(cnc3ccc(NCCN4CCOCC4)cc23)C#N)cc1Cl Show InChI InChI=1S/C22H20ClFN4OS/c23-19-12-17(2-3-20(19)24)30-22-15(13-25)14-27-21-4-1-16(11-18(21)22)26-5-6-28-7-9-29-10-8-28/h1-4,11-12,14,26H,5-10H2	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of Tpl2 kinase by ELISA				Bioorg Med Chem Lett 16: 6067-72 (2006) Article DOI: 10.1016/j.bmcl.2006.08.102 BindingDB Entry DOI: 10.7270/Q2W958TR
					More data for this Ligand-Target Pair