BDBM50195496 (4-amino-3,5-dichlorophenyl)((2R,6S)-2,6-dimethylpiperidin-1-yl)methanone::CHEMBL222668

SMILES: C[C@H]1CCC[C@@H](C)N1C(=O)c1cc(Cl)c(N)c(Cl)c1

InChI Key: InChIKey=QIIPLBRWXZECJB-DTORHVGOSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50195496   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 2 (Rattus norvegicus)	BDBM50195496 ((4-amino-3,5-dichlorophenyl)((2R,6S)-2,6-dimethylp...) Show SMILES C[C@H]1CCC[C@@H](C)N1C(=O)c1cc(Cl)c(N)c(Cl)c1 Show InChI InChI=1S/C14H18Cl2N2O/c1-8-4-3-5-9(2)18(8)14(19)10-6-11(15)13(17)12(16)7-10/h6-9H,3-5,17H2,1-2H3/t8-,9+	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of rat 11beta-HSD2				Bioorg Med Chem Lett 16: 6241-5 (2006) Article DOI: 10.1016/j.bmcl.2006.09.035 BindingDB Entry DOI: 10.7270/Q2B857R4
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 2 (Homo sapiens (Human))	BDBM50195496 ((4-amino-3,5-dichlorophenyl)((2R,6S)-2,6-dimethylp...) Show SMILES C[C@H]1CCC[C@@H](C)N1C(=O)c1cc(Cl)c(N)c(Cl)c1 Show InChI InChI=1S/C14H18Cl2N2O/c1-8-4-3-5-9(2)18(8)14(19)10-6-11(15)13(17)12(16)7-10/h6-9H,3-5,17H2,1-2H3/t8-,9+	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD2 by SPA				Bioorg Med Chem Lett 16: 6241-5 (2006) Article DOI: 10.1016/j.bmcl.2006.09.035 BindingDB Entry DOI: 10.7270/Q2B857R4
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50195496 ((4-amino-3,5-dichlorophenyl)((2R,6S)-2,6-dimethylp...) Show SMILES C[C@H]1CCC[C@@H](C)N1C(=O)c1cc(Cl)c(N)c(Cl)c1 Show InChI InChI=1S/C14H18Cl2N2O/c1-8-4-3-5-9(2)18(8)14(19)10-6-11(15)13(17)12(16)7-10/h6-9H,3-5,17H2,1-2H3/t8-,9+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1 expressed in Escherichia coli by SPA				Bioorg Med Chem Lett 16: 6241-5 (2006) Article DOI: 10.1016/j.bmcl.2006.09.035 BindingDB Entry DOI: 10.7270/Q2B857R4
					More data for this Ligand-Target Pair