BDBM50197984 (S)-2-{3-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-yl-2H-pyrazol-3-ylamino]-propionylamino}-5-guanidino-pentanoic acid methyl ester::CHEMBL238731

SMILES: [#6]-[#8]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#6]-[#7]-c1cc(nn1-c1ccc2ccccc2c1)-c1cc(Cl)cc(Cl)c1

InChI Key: InChIKey=HCAOSJGBOWJFLX-DEOSSOPVSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50197984   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50197984 ((S)-2-{3-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-y...) Show SMILES [#6]-[#8]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#6]-[#7]-c1cc(nn1-c1ccc2ccccc2c1)-c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C29H31Cl2N7O3/c1-41-28(40)24(7-4-11-35-29(32)33)36-27(39)10-12-34-26-17-25(20-13-21(30)16-22(31)14-20)37-38(26)23-9-8-18-5-2-3-6-19(18)15-23/h2-3,5-6,8-9,13-17,24,34H,4,7,10-12H2,1H3,(H,36,39)(H4,32,33,35)/t24-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity against human CCR2 receptor assessed as inhibition of MCP1-induced migration of human peripheral blood monocytes				Bioorg Med Chem Lett 17: 807-13 (2007) Article DOI: 10.1016/j.bmcl.2006.10.060 BindingDB Entry DOI: 10.7270/Q2P84BJD
					More data for this Ligand-Target Pair
C-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM50197984 ((S)-2-{3-[5-(3,5-dichloro-phenyl)-2-naphthalen-2-y...) Show SMILES [#6]-[#8]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#6]-[#7]-c1cc(nn1-c1ccc2ccccc2c1)-c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C29H31Cl2N7O3/c1-41-28(40)24(7-4-11-35-29(32)33)36-27(39)10-12-34-26-17-25(20-13-21(30)16-22(31)14-20)37-38(26)23-9-8-18-5-2-3-6-19(18)15-23/h2-3,5-6,8-9,13-17,24,34H,4,7,10-12H2,1H3,(H,36,39)(H4,32,33,35)/t24-/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Displacement of 125I-hMCP1 from CCR2 expressed in human peripheral blood monocytes after 60 mins				Bioorg Med Chem Lett 17: 807-13 (2007) Article DOI: 10.1016/j.bmcl.2006.10.060 BindingDB Entry DOI: 10.7270/Q2P84BJD
					More data for this Ligand-Target Pair