BindingDB PrimarySearch

BDBM50198035 CHEMBL227501::[(R)-2-methyl-1-(3'-methyl-biphenyl-4-sulfonylamino)-propyl]-phosphonic acid

SMILES: CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1cccc(C)c1)P(O)(O)=O

InChI Key: InChIKey=WNLZTTHHHYZJMB-QGZVFWFLSA-N

Data: 8 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50198035
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50198035 (CHEMBL227501 \| [(R)-2-methyl-1-(3'-methyl-biphenyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
Università "G. d'Annunzio" Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP9 expressed in mouse myeloma cells				Bioorg Med Chem 15: 791-9 (2006) Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T
Università "G. d'Annunzio" Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (MMP14) (Homo sapiens (Human))	BDBM50198035 (CHEMBL227501 \| [(R)-2-methyl-1-(3'-methyl-biphenyl...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Università "G. d'Annunzio" Curated by ChEMBL					Assay Description Inhibition of MMP14				Bioorg Med Chem 15: 791-9 (2006) Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T
Università "G. d'Annunzio" Curated by ChEMBL					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50198035 (CHEMBL227501 \| [(R)-2-methyl-1-(3'-methyl-biphenyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
Università "G. d'Annunzio" Curated by ChEMBL					Assay Description Inhibition of MMP1				Bioorg Med Chem 15: 791-9 (2006) Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T
Università "G. d'Annunzio" Curated by ChEMBL					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50198035 (CHEMBL227501 \| [(R)-2-methyl-1-(3'-methyl-biphenyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Università "G. d'Annunzio" Curated by ChEMBL					Assay Description Inhibition of human recombinant MMP2 expressed in mouse myeloma cells				Bioorg Med Chem 15: 791-9 (2006) Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T
Università "G. d'Annunzio" Curated by ChEMBL					More data for this Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7) (Homo sapiens (Human))	BDBM50198035 (CHEMBL227501 \| [(R)-2-methyl-1-(3'-methyl-biphenyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Università "G. d'Annunzio" Curated by ChEMBL					Assay Description Inhibition of MMP7				Bioorg Med Chem 15: 791-9 (2006) Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T
Università "G. d'Annunzio" Curated by ChEMBL					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM50198035 (CHEMBL227501 \| [(R)-2-methyl-1-(3'-methyl-biphenyl...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Università "G. d'Annunzio" Curated by ChEMBL					Assay Description Inhibition of MMP13				Bioorg Med Chem 15: 791-9 (2006) Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T
Università "G. d'Annunzio" Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50198035 (CHEMBL227501 \| [(R)-2-methyl-1-(3'-methyl-biphenyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Università "G. d'Annunzio" Curated by ChEMBL					Assay Description Inhibition of MMP8				Bioorg Med Chem 15: 791-9 (2006) Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T
Università "G. d'Annunzio" Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Stromelysin-1 (Homo sapiens (Human))	BDBM50198035 (CHEMBL227501 \| [(R)-2-methyl-1-(3'-methyl-biphenyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Università "G. d'Annunzio" Curated by ChEMBL					Assay Description Inhibition of MMP3				Bioorg Med Chem 15: 791-9 (2006) Article DOI: 10.1016/j.bmc.2006.10.047 BindingDB Entry DOI: 10.7270/Q2DR2V4T
Università "G. d'Annunzio" Curated by ChEMBL					More data for this Ligand-Target Pair