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SMILES: Nc1nccn2c(nc(-c3cccc(OCc4c(F)cccc4F)c3)c12)C1CCC1

InChI Key: InChIKey=YBDFEMULOWJQEV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50199641   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50199641 (1-(3-(2,6-difluorobenzyloxy)phenyl)-3-cyclobutylim...) Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4c(F)cccc4F)c3)c12)C1CCC1 Show InChI InChI=1S/C23H20F2N4O/c24-18-8-3-9-19(25)17(18)13-30-16-7-2-6-15(12-16)20-21-22(26)27-10-11-29(21)23(28-20)14-4-1-5-14/h2-3,6-12,14H,1,4-5,13H2,(H2,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	215	n/a	n/a	n/a	n/a	n/a	n/a
OSI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-IGF1R activity				Bioorg Med Chem Lett 17: 1091-7 (2007) Article DOI: 10.1016/j.bmcl.2006.11.016 BindingDB Entry DOI: 10.7270/Q2QZ29MB
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50199641 (1-(3-(2,6-difluorobenzyloxy)phenyl)-3-cyclobutylim...) Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4c(F)cccc4F)c3)c12)C1CCC1 Show InChI InChI=1S/C23H20F2N4O/c24-18-8-3-9-19(25)17(18)13-30-16-7-2-6-15(12-16)20-21-22(26)27-10-11-29(21)23(28-20)14-4-1-5-14/h2-3,6-12,14H,1,4-5,13H2,(H2,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
OSI Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cells				Bioorg Med Chem Lett 17: 1091-7 (2007) Article DOI: 10.1016/j.bmcl.2006.11.016 BindingDB Entry DOI: 10.7270/Q2QZ29MB
					More data for this Ligand-Target Pair