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SMILES: Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1CC[C@@H](CC1)C(=O)N1CCCCC1

InChI Key: InChIKey=TZDLCCINNUNLRZ-RQNOJGIXSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50199658   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50199658
PNG
(CHEMBL394136 | trans-4-(8-amino-1-(3-(benzyloxy)ph...)
Show SMILES Nc1nccn2c(nc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1CC[C@@H](CC1)C(=O)N1CCCCC1 |wU:27.34,wD:24.27,(6.94,-16.4,;6.95,-17.94,;5.63,-18.71,;5.62,-20.26,;6.96,-21.03,;8.29,-20.26,;9.77,-20.73,;10.68,-19.48,;9.77,-18.22,;10.24,-16.76,;9.21,-15.63,;9.68,-14.16,;11.19,-13.84,;12.22,-14.98,;13.73,-14.66,;14.76,-15.8,;16.27,-15.48,;17.29,-16.63,;18.79,-16.31,;19.27,-14.84,;18.23,-13.7,;16.73,-14.02,;11.75,-16.44,;8.29,-18.7,;10.25,-22.2,;9.21,-23.35,;9.68,-24.81,;11.19,-25.13,;12.22,-23.99,;11.75,-22.52,;11.66,-26.6,;10.63,-27.74,;13.17,-26.92,;13.62,-28.39,;15.12,-28.71,;16.16,-27.58,;15.69,-26.11,;14.19,-25.78,)|
Show InChI InChI=1S/C31H35N5O2/c32-29-28-27(25-10-7-11-26(20-25)38-21-22-8-3-1-4-9-22)34-30(36(28)19-16-33-29)23-12-14-24(15-13-23)31(37)35-17-5-2-6-18-35/h1,3-4,7-11,16,19-20,23-24H,2,5-6,12-15,17-18,21H2,(H2,32,33)/t23-,24-
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n/an/a 3.40E+3n/an/an/an/an/an/a



OSI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-IGF1R activity

Bioorg Med Chem Lett 17: 1091-7 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.016
BindingDB Entry DOI: 10.7270/Q2QZ29MB
More data for this
Ligand-Target Pair