Found 12 hits for monomerid = 50200975 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50200975
(CHEMBL3916621 | US10087187, Compound 2)Show SMILES Cc1c(Cc2c(CNCCS(C)(=O)=O)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C23H29F3N6O3S/c1-15-16(4-3-5-17(15)23(24,25)26)12-20-19(14-28-6-11-36(2,33)34)29-22-18(27)13-21(30-32(20)22)31-7-9-35-10-8-31/h3-5,13,28H,6-12,14,27H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC
Curated by ChEMBL
| Assay Description Binding affinity to human PI3Kbeta (118 to 1070 residues) expressed in mammalian expression system by KINOMEscan assay |
ACS Med Chem Lett 7: 1012-1013 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00406 BindingDB Entry DOI: 10.7270/Q2N29ZX9 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50200975
(CHEMBL3916621 | US10087187, Compound 2)Show SMILES Cc1c(Cc2c(CNCCS(C)(=O)=O)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C23H29F3N6O3S/c1-15-16(4-3-5-17(15)23(24,25)26)12-20-19(14-28-6-11-36(2,33)34)29-22-18(27)13-21(30-32(20)22)31-7-9-35-10-8-31/h3-5,13,28H,6-12,14,27H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 8.13E+3 | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC
Curated by ChEMBL
| Assay Description Binding affinity to human PI3Kalpha (108 to 1068 residues) expressed in mammalian expression system by KINOMEscan assay |
ACS Med Chem Lett 7: 1012-1013 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00406 BindingDB Entry DOI: 10.7270/Q2N29ZX9 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50200975
(CHEMBL3916621 | US10087187, Compound 2)Show SMILES Cc1c(Cc2c(CNCCS(C)(=O)=O)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C23H29F3N6O3S/c1-15-16(4-3-5-17(15)23(24,25)26)12-20-19(14-28-6-11-36(2,33)34)29-22-18(27)13-21(30-32(20)22)31-7-9-35-10-8-31/h3-5,13,28H,6-12,14,27H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 178 | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC
Curated by ChEMBL
| Assay Description Binding affinity to human PI3Kdelta (108 to 1044 residues) expressed in mammalian expression system by KINOMEscan assay |
ACS Med Chem Lett 7: 1012-1013 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00406 BindingDB Entry DOI: 10.7270/Q2N29ZX9 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50200975
(CHEMBL3916621 | US10087187, Compound 2)Show SMILES Cc1c(Cc2c(CNCCS(C)(=O)=O)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C23H29F3N6O3S/c1-15-16(4-3-5-17(15)23(24,25)26)12-20-19(14-28-6-11-36(2,33)34)29-22-18(27)13-21(30-32(20)22)31-7-9-35-10-8-31/h3-5,13,28H,6-12,14,27H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 138 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC
Curated by ChEMBL
| Assay Description Inhibition of PI3Kbeta in human PC3 cells assessed as suppression of AKT phosphorylation at Ser473 after 60 mins by ELISA |
ACS Med Chem Lett 7: 1012-1013 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00406 BindingDB Entry DOI: 10.7270/Q2N29ZX9 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50200975
(CHEMBL3916621 | US10087187, Compound 2)Show SMILES Cc1c(Cc2c(CNCCS(C)(=O)=O)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C23H29F3N6O3S/c1-15-16(4-3-5-17(15)23(24,25)26)12-20-19(14-28-6-11-36(2,33)34)29-22-18(27)13-21(30-32(20)22)31-7-9-35-10-8-31/h3-5,13,28H,6-12,14,27H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 186 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC
Curated by ChEMBL
| Assay Description Inhibition of PI3Kbeta in human PC3 cells assessed as suppression of AKT phosphorylation at Thr308 after 60 mins by ELISA |
ACS Med Chem Lett 7: 1012-1013 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00406 BindingDB Entry DOI: 10.7270/Q2N29ZX9 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50200975
(CHEMBL3916621 | US10087187, Compound 2)Show SMILES Cc1c(Cc2c(CNCCS(C)(=O)=O)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C23H29F3N6O3S/c1-15-16(4-3-5-17(15)23(24,25)26)12-20-19(14-28-6-11-36(2,33)34)29-22-18(27)13-21(30-32(20)22)31-7-9-35-10-8-31/h3-5,13,28H,6-12,14,27H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | n/a | 2.34E+4 | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa... |
US Patent US10087187 (2018)
BindingDB Entry DOI: 10.7270/Q2M61N9J |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50200975
(CHEMBL3916621 | US10087187, Compound 2)Show SMILES Cc1c(Cc2c(CNCCS(C)(=O)=O)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C23H29F3N6O3S/c1-15-16(4-3-5-17(15)23(24,25)26)12-20-19(14-28-6-11-36(2,33)34)29-22-18(27)13-21(30-32(20)22)31-7-9-35-10-8-31/h3-5,13,28H,6-12,14,27H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 2.34E+4 | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC
Curated by ChEMBL
| Assay Description Binding affinity to human MTOR (1382 to 2549 residues) expressed in mammalian expression system by KINOMEscan assay |
ACS Med Chem Lett 7: 1012-1013 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00406 BindingDB Entry DOI: 10.7270/Q2N29ZX9 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
(Homo sapiens (Human)) | BDBM50200975
(CHEMBL3916621 | US10087187, Compound 2)Show SMILES Cc1c(Cc2c(CNCCS(C)(=O)=O)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C23H29F3N6O3S/c1-15-16(4-3-5-17(15)23(24,25)26)12-20-19(14-28-6-11-36(2,33)34)29-22-18(27)13-21(30-32(20)22)31-7-9-35-10-8-31/h3-5,13,28H,6-12,14,27H2,1-2H3 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | n/a | 8.13E+3 | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa... |
US Patent US10087187 (2018)
BindingDB Entry DOI: 10.7270/Q2M61N9J |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
(Homo sapiens (Human)) | BDBM50200975
(CHEMBL3916621 | US10087187, Compound 2)Show SMILES Cc1c(Cc2c(CNCCS(C)(=O)=O)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C23H29F3N6O3S/c1-15-16(4-3-5-17(15)23(24,25)26)12-20-19(14-28-6-11-36(2,33)34)29-22-18(27)13-21(30-32(20)22)31-7-9-35-10-8-31/h3-5,13,28H,6-12,14,27H2,1-2H3 | NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa... |
US Patent US10087187 (2018)
BindingDB Entry DOI: 10.7270/Q2M61N9J |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50200975
(CHEMBL3916621 | US10087187, Compound 2)Show SMILES Cc1c(Cc2c(CNCCS(C)(=O)=O)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C23H29F3N6O3S/c1-15-16(4-3-5-17(15)23(24,25)26)12-20-19(14-28-6-11-36(2,33)34)29-22-18(27)13-21(30-32(20)22)31-7-9-35-10-8-31/h3-5,13,28H,6-12,14,27H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | n/a | 178 | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa... |
US Patent US10087187 (2018)
BindingDB Entry DOI: 10.7270/Q2M61N9J |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50200975
(CHEMBL3916621 | US10087187, Compound 2)Show SMILES Cc1c(Cc2c(CNCCS(C)(=O)=O)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C23H29F3N6O3S/c1-15-16(4-3-5-17(15)23(24,25)26)12-20-19(14-28-6-11-36(2,33)34)29-22-18(27)13-21(30-32(20)22)31-7-9-35-10-8-31/h3-5,13,28H,6-12,14,27H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | n/a | >3.02E+4 | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
US Patent
| Assay Description Kinase enzyme binding affinities of compounds disclosed herein were determined using the KINOMEscan technology performed by DiscoveRx Corporation, Sa... |
US Patent US10087187 (2018)
BindingDB Entry DOI: 10.7270/Q2M61N9J |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50200975
(CHEMBL3916621 | US10087187, Compound 2)Show SMILES Cc1c(Cc2c(CNCCS(C)(=O)=O)nc3c(N)cc(nn23)N2CCOCC2)cccc1C(F)(F)F Show InChI InChI=1S/C23H29F3N6O3S/c1-15-16(4-3-5-17(15)23(24,25)26)12-20-19(14-28-6-11-36(2,33)34)29-22-18(27)13-21(30-32(20)22)31-7-9-35-10-8-31/h3-5,13,28H,6-12,14,27H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | >3.02E+4 | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC
Curated by ChEMBL
| Assay Description Binding affinity to human PI3Kgamma (144 to 1102 residues) expressed in mammalian expression system by KINOMEscan assay |
ACS Med Chem Lett 7: 1012-1013 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00406 BindingDB Entry DOI: 10.7270/Q2N29ZX9 |
More data for this Ligand-Target Pair | |