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SMILES: Cc1nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n2c1CN1CCOCC1

InChI Key: InChIKey=WJIMFWKSPBKAGE-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50203620   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50203620
PNG
(8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-3-morpho...)
Show SMILES Cc1nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n2c1CN1CCOCC1 |(-8.79,-40.1,;-7.37,-39.52,;-6.06,-40.33,;-4.88,-39.35,;-3.34,-39.24,;-2.35,-40.42,;-.84,-40.15,;-.32,-38.7,;.15,-41.32,;-.38,-42.78,;.61,-43.96,;-1.9,-43.04,;-2.89,-41.86,;-4.4,-42.13,;-2.97,-37.75,;-1.6,-37.03,;-1.54,-35.48,;-2.92,-34.59,;-4.22,-35.38,;-4.28,-36.92,;-5.46,-37.91,;-7,-38.03,;-7.99,-36.85,;-7.46,-35.4,;-5.95,-35.14,;-5.43,-33.7,;-6.41,-32.52,;-7.93,-32.78,;-8.46,-34.23,)|
Show InChI InChI=1S/C22H24ClN5O/c1-14-11-15(2)20(17(23)12-14)28-21-18(5-4-6-24-21)27-19(16(3)25-22(27)28)13-26-7-9-29-10-8-26/h4-6,11-12H,7-10,13H2,1-3H3
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Article
PubMed
 1.40E+3n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF stimulated cAMP production

Bioorg Med Chem Lett 17: 2026-30 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.008
BindingDB Entry DOI: 10.7270/Q21R6Q5Q
More data for this
Ligand-Target Pair