BDBM50205147 CHEMBL3911762

SMILES: CCn1c(nn(-c2ccccc2OC(F)(F)F)c1=O)C(=O)Nc1ccc(Oc2ccnc3cc(OCCCN4CCC(C)CC4)c(OC)cc23)c(F)c1

InChI Key: InChIKey=VGASWFVJNDNMJE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50205147   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50205147 (CHEMBL3911762) Show SMILES CCn1c(nn(-c2ccccc2OC(F)(F)F)c1=O)C(=O)Nc1ccc(Oc2ccnc3cc(OCCCN4CCC(C)CC4)c(OC)cc23)c(F)c1 Show InChI InChI=1S/C37H38F4N6O6/c1-4-46-34(44-47(36(46)49)28-8-5-6-9-31(28)53-37(39,40)41)35(48)43-24-10-11-30(26(38)20-24)52-29-12-15-42-27-22-33(32(50-3)21-25(27)29)51-19-7-16-45-17-13-23(2)14-18-45/h5-6,8-12,15,20-23H,4,7,13-14,16-19H2,1-3H3,(H,43,48)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-MET (unknown origin) using poly(Glu, Tyr)4:1 as substrate after 30 mins by HTRF assay				Eur J Med Chem 123: 431-446 (2016) Article DOI: 10.1016/j.ejmech.2016.07.059 BindingDB Entry DOI: 10.7270/Q2KK9DR0
					More data for this Ligand-Target Pair