BDBM50205859 (R)-10-chloro-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino-[2,1-a]isoindol-6(2H)-one::CHEMBL375575

SMILES: FC(F)(F)c1ccc(Cl)c2[C@@H]3CNCCN3C(=O)c12

InChI Key: InChIKey=JYQPQWBAHAQSSY-QMMMGPOBSA-N

Data: 3 KI  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50205859   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50205859 ((R)-10-chloro-1,3,4,10b-tetrahydro-7-trifluorometh...) Show SMILES FC(F)(F)c1ccc(Cl)c2[C@@H]3CNCCN3C(=O)c12 Show InChI InChI=1S/C12H10ClF3N2O/c13-7-2-1-6(12(14,15)16)9-10(7)8-5-17-3-4-18(8)11(9)19/h1-2,8,17H,3-5H2/t8-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.08E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]DOI from human recombinant 5HT2C expressed in HEK293E cells				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50205859 ((R)-10-chloro-1,3,4,10b-tetrahydro-7-trifluorometh...) Show SMILES FC(F)(F)c1ccc(Cl)c2[C@@H]3CNCCN3C(=O)c12 Show InChI InChI=1S/C12H10ClF3N2O/c13-7-2-1-6(12(14,15)16)9-10(7)8-5-17-3-4-18(8)11(9)19/h1-2,8,17H,3-5H2/t8-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.47E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Displacement of [125I]DOI from human recombinant 5HT2A expressed in HEK293E cells				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50205859 ((R)-10-chloro-1,3,4,10b-tetrahydro-7-trifluorometh...) Show SMILES FC(F)(F)c1ccc(Cl)c2[C@@H]3CNCCN3C(=O)c12 Show InChI InChI=1S/C12H10ClF3N2O/c13-7-2-1-6(12(14,15)16)9-10(7)8-5-17-3-4-18(8)11(9)19/h1-2,8,17H,3-5H2/t8-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.03E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50205859 ((R)-10-chloro-1,3,4,10b-tetrahydro-7-trifluorometh...) Show SMILES FC(F)(F)c1ccc(Cl)c2[C@@H]3CNCCN3C(=O)c12 Show InChI InChI=1S/C12H10ClF3N2O/c13-7-2-1-6(12(14,15)16)9-10(7)8-5-17-3-4-18(8)11(9)19/h1-2,8,17H,3-5H2/t8-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50205859 ((R)-10-chloro-1,3,4,10b-tetrahydro-7-trifluorometh...) Show SMILES FC(F)(F)c1ccc(Cl)c2[C@@H]3CNCCN3C(=O)c12 Show InChI InChI=1S/C12H10ClF3N2O/c13-7-2-1-6(12(14,15)16)9-10(7)8-5-17-3-4-18(8)11(9)19/h1-2,8,17H,3-5H2/t8-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50205859 ((R)-10-chloro-1,3,4,10b-tetrahydro-7-trifluorometh...) Show SMILES FC(F)(F)c1ccc(Cl)c2[C@@H]3CNCCN3C(=O)c12 Show InChI InChI=1S/C12H10ClF3N2O/c13-7-2-1-6(12(14,15)16)9-10(7)8-5-17-3-4-18(8)11(9)19/h1-2,8,17H,3-5H2/t8-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a
Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay				J Med Chem 50: 1365-79 (2007) Article DOI: 10.1021/jm0612968 BindingDB Entry DOI: 10.7270/Q2XP74M8
					More data for this Ligand-Target Pair