BDBM50212518 4'-[7-(tert-butylamino-methyl)-1,4-dihydro-indeno[1,2-c]pyrazol-3-yl]-biphenyl-4-ol::CHEMBL234865

SMILES: CC(C)(C)NCc1ccc2Cc3c([nH]nc3-c3ccc(cc3)-c3ccc(O)cc3)-c2c1

InChI Key: InChIKey=ZZWJYCUEVXJKDX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50212518   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50212518 (4'-[7-(tert-butylamino-methyl)-1,4-dihydro-indeno[...) Show SMILES CC(C)(C)NCc1ccc2Cc3c([nH]nc3-c3ccc(cc3)-c3ccc(O)cc3)-c2c1 Show InChI InChI=1S/C27H27N3O/c1-27(2,3)28-16-17-4-5-21-15-24-25(29-30-26(24)23(21)14-17)20-8-6-18(7-9-20)19-10-12-22(31)13-11-19/h4-14,28,31H,15-16H2,1-3H3,(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of recombinant CHK-mediated Cdc25C phosphorylation after 30 mins				Bioorg Med Chem Lett 17: 3618-23 (2007) Article DOI: 10.1016/j.bmcl.2007.04.055 BindingDB Entry DOI: 10.7270/Q2DR2V6Q
					More data for this Ligand-Target Pair				3D Structure (docked)