BDBM50216378 CHEMBL231540::isoquinolinesulfon-5-yl-[2-oxo-2-(4-o-tolylpiperazin-1-yl)ethyl]amide

SMILES: Cc1ccccc1N1CCN(CC1)C(=O)CNS(=O)(=O)c1cccc2cnccc12

InChI Key: InChIKey=UESPMKNXKWMHAW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50216378   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM50216378 (CHEMBL231540 | isoquinolinesulfon-5-yl-[2-oxo-2-(4...) Show SMILES Cc1ccccc1N1CCN(CC1)C(=O)CNS(=O)(=O)c1cccc2cnccc12 Show InChI InChI=1S/C22H24N4O3S/c1-17-5-2-3-7-20(17)25-11-13-26(14-12-25)22(27)16-24-30(28,29)21-8-4-6-18-15-23-10-9-19(18)21/h2-10,15,24H,11-14,16H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Università di Ferrara Curated by ChEMBL					Assay Description Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as effect on intracellular calcium influx				J Med Chem 50: 3706-15 (2007) Article DOI: 10.1021/jm070443e BindingDB Entry DOI: 10.7270/Q2PN95CS
					More data for this Ligand-Target Pair